A systematic review of fetal genes as biomarkers of cardiac hypertrophy in rodent models of diabetes

Emily J Cox; Susan A Marsh

doi:10.1371/journal.pone.0092903

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A systematic review of fetal genes as biomarkers of cardiac hypertrophy in rodent models of diabetes

Journal article

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A systematic review of fetal genes as biomarkers of cardiac hypertrophy in rodent models of diabetes

Emily J Cox and Susan A Marsh

PloS one, Vol.9(3), pp.e92903-e92903

2014

DOI: https://doi.org/10.1371/journal.pone.0092903

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https://hdl.handle.net/2376/101659

PMCID: PMC3963983

PMID: 24663494

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Abstract

Biomarkers - metabolism

Diabetic Cardiomyopathies - genetics

Animals

Diabetic Cardiomyopathies - metabolism

Humans

Diabetes Mellitus, Experimental - genetics

Rats

Mice

Cardiomegaly - genetics

Diabetes Mellitus, Experimental - metabolism

Cardiomegaly - metabolism

Pathological cardiac hypertrophy activates a suite of genes called the fetal gene program (FGP). Pathological hypertrophy occurs in diabetic cardiomyopathy (DCM); therefore, the FGP is widely used as a biomarker of DCM in animal studies. However, it is unknown whether the FGP is a consistent marker of hypertrophy in rodent models of diabetes. Therefore, we analyzed this relationship in 94 systematically selected studies. Results showed that diabetes induced with cytotoxic glucose analogs such as streptozotocin was associated with decreased cardiac weight, but genetic or diet-induced models of diabetes were significantly more likely to show cardiac hypertrophy (P<0.05). Animal strain, sex, age, and duration of diabetes did not moderate this effect. There were no correlations between the heart weight:body weight index and mRNA or protein levels of the fetal genes α-myosin heavy chain (α-MHC) or β-MHC, sarco/endoplasmic reticulum Ca2+-ATPase, atrial natriuretic peptide (ANP), or brain natriuretic peptide. The only correlates of non-indexed heart weight were the protein levels of α-MHC (Spearman's ρ = 1, P<0.05) and ANP (ρ = -0.73, P<0.05). These results indicate that most commonly measured genes in the FGP are confounded by diabetogenic methods, and are not associated with cardiac hypertrophy in rodent models of diabetes.

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Title: A systematic review of fetal genes as biomarkers of cardiac hypertrophy in rodent models of diabetes
Creators: Emily J Cox - Graduate Program in Pharmaceutical Sciences, College of Pharmacy, Washington State University, Spokane, Washington, United States of America
Susan A Marsh - Department of Experimental and Systems Pharmacology, College of Pharmacy, Washington State University, Spokane, Washington, United States of America
Publication Details: PloS one, Vol.9(3), pp.e92903-e92903
Academic Unit: Pharmaceutical Sciences, Department of
Publisher: United States
Grant note: R15 HL104549 / NHLBI NIH HHS HL-104549 / NHLBI NIH HHS
Identifiers: 99900546620901842
Language: English
Resource Type: Journal article