Journal article
A variable-energy electron microbeam: a unique modality for targeted low-LET radiation
Radiation research, Vol.164(5), pp.695-700
11/2005
Handle:
https://hdl.handle.net/2376/114633
PMID: 16238449
Abstract
We have designed and constructed a low-cost, variable-energy low-LET electron microbeam that uses energetic electrons to mimic radiation damage produced by gamma and X rays. The microbeam can access lower regions of the LET spectrum, similar to conventional X-ray or 60Co gamma-ray sources. The device has two operating modes, as a conventional microbeam targeting single cells or subpopulations of cells or as a pseudo broad-beam source allowing for direct comparison with conventional sources. By varying the incident electron energy, the target cells can be selectively exposed to different parts of the energetic electron tracks, including the track ends.
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Details
- Title
- A variable-energy electron microbeam: a unique modality for targeted low-LET radiation
- Creators
- Marianne B Sowa - Pacific Northwest National Laboratory, Richland, Washington 99352, USA. Marianne.sowa@pnl.govMark K MurphyJohn H MillerJoseph C McDonaldDaniel J StromGregory A Kimmel
- Publication Details
- Radiation research, Vol.164(5), pp.695-700
- Academic Unit
- Engineering and Applied Sciences (TRIC), School of
- Publisher
- United States
- Identifiers
- 99900547955501842
- Language
- English
- Resource Type
- Journal article