Journal article
A versatile strategy for the synthesis of 2,6-disubstituted dihydropyranones
Journal of organic chemistry, Vol.72(11), pp.4280-4283
05/25/2007
Handle:
https://hdl.handle.net/2376/116683
PMID: 17447817
Abstract
A concise synthesis of 2,6-disubstituted dihydropyranones was developed. This sequence is based on the Smith three-component dithiane linchpin coupling strategy. By simply switching the order of epoxide addition in the linchpin coupling step, two analogous dihydropyranones were prepared in good yield from the same starting materials. This sequence allows for considerable flexibility in the nature of R(1) and R(2) groups, which facilitates the preparation of a diverse array of 2,6-disubstituted dihydropyranones.
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Details
- Title
- A versatile strategy for the synthesis of 2,6-disubstituted dihydropyranones
- Creators
- Hua Wang - Department of Chemistry, Washington State University, Pullman, Washington 99164, USABrian J ShuhlerMing Xian
- Publication Details
- Journal of organic chemistry, Vol.72(11), pp.4280-4283
- Academic Unit
- Chemistry, Department of
- Publisher
- United States
- Identifiers
- 99900547622101842
- Language
- English
- Resource Type
- Journal article