AT4 receptors: Specificity and distribution

Joseph W Harding; John W Wright; Geoffrey N Swanson; Jodie M Hanesworth; Luke T Krebs

doi:10.1038/ki.1994.432

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AT4 receptors: Specificity and distribution

Journal article

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AT4 receptors: Specificity and distribution

Joseph W Harding, John W Wright, Geoffrey N Swanson, Jodie M Hanesworth and Luke T Krebs

Kidney international, Vol.46(6), pp.1510-1512

12/1994

DOI: https://doi.org/10.1038/ki.1994.432

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https://hdl.handle.net/2376/107393

PMID: 7699992

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Abstract

AT4 receptor: Specificity and distribution. The AT4 receptor specifically binds Angiotensin (Ang) IV and is distinct from the AT1 and AT2 receptors which bind Ang II and Ang III. The AT4 receptor in bovine adrenal cortex has a Kd of 0.74 ± 0.14nM and a Bmax of 3.82 ± 1.12 pmol/mg prot. Competition curves demonstrated the following rank order of affinity: Ang IV > Ang III > d-Arg - Ang II > Sar1, Ile8 - Ang II = Ang II = Ang II (1-7) > DuP753 = CGP42112A = PD 123177. AT4 receptors were present in many tissues from several mammalian species including human and monkey. AT4 and AT1/AT2 receptors revealed a differential distribution in the rat kidney.

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Title: AT4 receptors: Specificity and distribution
Creators: Joseph W Harding - Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, and Department of Psychology, Washington State University, Pullman, Washington, USA
John W Wright - Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, and Department of Psychology, Washington State University, Pullman, Washington, USA
Geoffrey N Swanson - Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, and Department of Psychology, Washington State University, Pullman, Washington, USA
Jodie M Hanesworth - Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, and Department of Psychology, Washington State University, Pullman, Washington, USA
Luke T Krebs - Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, and Department of Psychology, Washington State University, Pullman, Washington, USA
Publication Details: Kidney international, Vol.46(6), pp.1510-1512
Academic Unit: Psychology, Department of; Integrative Physiology and Neuroscience, Department of
Publisher: Elsevier Inc
Identifiers: 99900547149001842
Language: English
Resource Type: Journal article