Journal article
Absence of Endogenous Circadian Rhythmicity in Blood Pressure?
American journal of hypertension, Vol.11(3), pp.373-377
1998
Handle:
https://hdl.handle.net/2376/114458
PMID: 9544879
Abstract
Currently available evidence reveals a predominant role of exogenous (so-called “masking”) factors in the 24 h variation of blood pressure in humans. The existence of a (minor) endogenous circadian factor cannot be excluded, however. This possibility was tested by applying the rigorous unmasking conditions of the constant-routine protocol, that is, strict bed rest in a separate bedroom, total sleep deprivation, constant ambient temperature and illumination, and hourly equicaloric food and liquid intake. Twenty-five normotensive young individuals were subjected to a 26 h constant-routine procedure while hourly measurements were made of their blood pressure and heart rate. Repeated-measures analysis of variance failed to show a significant 24 h variation of blood pressure. The power of this test appeared satisfactorily high (>0.95). Heart rate, however, exhibited a significant circadian pattern, with a range of 6.7 beats/min (10% of the 24 h mean value). Moreover, the timing of the 24 h heart rate curves differed significantly between so-called morning (n = 10) and evening (n = 9) individuals. Mean peak values for the morning-types occurred at 11
am, for the evening types nearly 6 h later. In conclusion, no evidence was found for the involvement of a circadian oscillator in the regulation of blood pressure.
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Details
- Title
- Absence of Endogenous Circadian Rhythmicity in Blood Pressure?
- Creators
- Gerard A Kerkhof - Department of Physiology, University of Leiden, Leiden, The NetherlandsHans P.A Van Dongen - Department of Physiology, University of Leiden, Leiden, The NetherlandsAdolf C Bobbert - Department of Physiology, University of Leiden, Leiden, The Netherlands
- Publication Details
- American journal of hypertension, Vol.11(3), pp.373-377
- Academic Unit
- Medical Education and Clinical Science, Department of
- Publisher
- Elsevier Inc
- Identifiers
- 99900547589001842
- Language
- English
- Resource Type
- Journal article