Journal article
Acute Cocaine Increases Interleukin-1β mRNA and Immunoreactive Cells in the Cortex and Nucleus Accumbens
Neurochemical research, Vol.36(4), pp.686-692
04/2011
Handle:
https://hdl.handle.net/2376/101488
PMCID: PMC5427711
PMID: 21399909
Abstract
The cytokine, interleukin-1
β
(IL1
β
) is a sleep regulatory substance whose expression is enhanced in response to neuronal stimulation. In this study, IL1
β
mRNA and immunoreactivity (IR) are evaluated after acute cocaine. First, IL1
β
mRNA levels were measured at the start or end of the light period after saline or acute exposure to a low dose of cocaine (5 mg/kg, intraperitoneal (ip)). IL1
β
mRNA levels after an acute exposure to cocaine (5 mg/kg, ip) at dark onset were significantly higher than those obtained from rats sacrificed after an acute exposure to saline in the piriform and somatosensory cortex, and nucleus accumbens. Acute exposure of cocaine at 5 mg/kg at dark onset also increased the number of IL1
β
-immunoreactive astrocytes in layer I–V of the prefrontal cortex, somatosensory cortex and nucleus accumbens. These data suggest that IL1
β
mRNA and protein levels in some of the dopaminergically innervated brain regions are responsive to cocaine.
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Details
- Title
- Acute Cocaine Increases Interleukin-1β mRNA and Immunoreactive Cells in the Cortex and Nucleus Accumbens
- Creators
- Barbara A Sorg - Washington Alcohol and Drug Abuse and Neuroscience Program, Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, College of Veterinary Medicine, Washington State University, PO Box 646520, Pullman, WA 99164-6520, USAJames M Krueger - Washington Alcohol and Drug Abuse and Neuroscience Program, Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, College of Veterinary Medicine, Washington State University, PO Box 646520, Pullman, WA 99164-6520, USALynn Churchill - Washington Alcohol and Drug Abuse and Neuroscience Program, Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, College of Veterinary Medicine, Washington State University, PO Box 646520, Pullman, WA 99164-6520, USACassia N Cearley - Chicago, IL, USAKelly Blindheim - University of East Medical Center, Quezon City, Phillipines
- Publication Details
- Neurochemical research, Vol.36(4), pp.686-692
- Academic Unit
- Integrative Physiology and Neuroscience, Department of
- Identifiers
- 99900546653801842
- Language
- English
- Resource Type
- Journal article