Journal article
Additional Diagnostic Yield of Adding Serology to PCR in Diagnosing Viral Acute Respiratory Infections in Kenyan Patients 5 Years of Age and Older
Clinical and vaccine immunology, Vol.20(1), pp.113-114
01/2013
Handle:
https://hdl.handle.net/2376/114907
PMCID: PMC3535781
PMID: 23114699
Abstract
The role of serology in the setting of PCR-based diagnosis of acute respiratory infections (ARIs) is unclear. We found that acute- and convalescent-phase paired-sample serologic testing increased the diagnostic yield of naso/oropharyngeal swabs for influenza virus, respiratory syncytial virus (RSV), human metapneumovirus, adenovirus, and parainfluenza viruses beyond PCR by 0.4% to 10.7%. Although still limited for clinical use, serology, along with PCR, can maximize etiologic diagnosis in epidemiologic studies.
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Details
- Title
- Additional Diagnostic Yield of Adding Serology to PCR in Diagnosing Viral Acute Respiratory Infections in Kenyan Patients 5 Years of Age and Older
- Creators
- Daniel R Feikin - International Emerging Infections Program, Global Disease Detection Branch, Centers for Disease Control and Prevention-KenyaM. Kariuki Njenga - International Emerging Infections Program, Global Disease Detection Branch, Centers for Disease Control and Prevention-KenyaGodfrey Bigogo - International Emerging Infections Program, Global Disease Detection Branch, Centers for Disease Control and Prevention-KenyaBarrack Aura - International Emerging Infections Program, Global Disease Detection Branch, Centers for Disease Control and Prevention-KenyaStella Gikunju - International Emerging Infections Program, Global Disease Detection Branch, Centers for Disease Control and Prevention-KenyaAmanda Balish - National Center for Immunizations and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USAMark A Katz - Kenya Medical Research Institute/Centers for Disease Control and Prevention Public Health and Research Collaboration, Kisumu, KenyaDean Erdman - National Center for Immunizations and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USARobert F Breiman - International Emerging Infections Program, Global Disease Detection Branch, Centers for Disease Control and Prevention-Kenya
- Publication Details
- Clinical and vaccine immunology, Vol.20(1), pp.113-114
- Academic Unit
- Paul G. Allen School for Global Animal Health
- Publisher
- American Society for Microbiology; 1752 N St., N.W., Washington, DC
- Identifiers
- 99900547336201842
- Language
- English
- Resource Type
- Journal article