Adhesion molecules in establishing retinal circuitry

Peter G Fuerst; Robert W Burgess

doi:10.1016/j.conb.2009.07.013

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Adhesion molecules in establishing retinal circuitry

Journal article

Open access

Peer reviewed

Adhesion molecules in establishing retinal circuitry

Peter G Fuerst and Robert W Burgess

Current opinion in neurobiology, Vol.19(4), pp.389-394

08/2009

DOI: https://doi.org/10.1016/j.conb.2009.07.013

Handle:

https://hdl.handle.net/2376/106803

PMCID: PMC2752058

PMID: 19660931

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Abstract

masking

mosaics

Dscam

tiling

adhesion code

The formation of neural circuits requires molecular mechanisms to confer cell identity, to establish appropriate dendritic arbors, and to space cell bodies within groups of homotypic neurons. Recent work in a variety of organisms has implicated cell adhesion molecules in these processes. The DSCAMs in particular have functions including cell identity and self-avoidance through repulsion in Drosophila , differential adhesion and synaptic pairing in chick retina, and the masking of adhesion within specific cell types in the mouse retina. These differences in molecular function between different organisms, and potentially different cell types within a single tissue, emphasize how seemingly subtle distinctions may be important for deciphering this molecular adhesion code.

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Details

Title: Adhesion molecules in establishing retinal circuitry
Creators: Peter G Fuerst
Robert W Burgess
Publication Details: Current opinion in neurobiology, Vol.19(4), pp.389-394
Academic Unit: Center for Reproductive Biology
Identifiers: 99900547101001842
Language: English
Resource Type: Journal article