Journal article
Adverse Drug Reactions in Veterinary Patients Associated with Drug Transporters
The Veterinary clinics of North America. Small animal practice, Vol.43(5), pp.1067-1078
09/2013
Handle:
https://hdl.handle.net/2376/114248
PMID: 23890239
Abstract
For many drugs used in veterinary practice, plasma and tissue concentrations are highly dependent on the activity of drug transporters. This article describes how functional changes in drug transporters, whether mediated by genetic variability or drug-drug interactions, affect drug disposition and, ultimately, drug safety and efficacy in veterinary patients. A greater understanding of species, breed, and individual (genetic) differences in drug transporter function, as well as drug-drug interactions involving drug transporters, will result in improved strategies for drug design and will enable veterinarians to incorporate individualized medicine in their practices.
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Details
- Title
- Adverse Drug Reactions in Veterinary Patients Associated with Drug Transporters
- Creators
- Katrina L Mealey - Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99164-6610, USA
- Publication Details
- The Veterinary clinics of North America. Small animal practice, Vol.43(5), pp.1067-1078
- Academic Unit
- Veterinary Clinical Sciences, Department of
- Publisher
- Elsevier Inc
- Identifiers
- 99900547580601842
- Language
- English
- Resource Type
- Journal article