Affective Cue-Induced Escalation of Alcohol Self-Administration and Increased 22-kHz Ultrasonic Vocalizations during Alcohol Withdrawal: Role of Kappa-Opioid Receptors

Anthony L Berger; Angela M Williams; Molly M McGinnis; Brendan M Walker

doi:10.1038/npp.2012.229

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Affective Cue-Induced Escalation of Alcohol Self-Administration and Increased 22-kHz Ultrasonic Vocalizations during Alcohol Withdrawal: Role of Kappa-Opioid Receptors

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Affective Cue-Induced Escalation of Alcohol Self-Administration and Increased 22-kHz Ultrasonic Vocalizations during Alcohol Withdrawal: Role of Kappa-Opioid Receptors

Anthony L Berger, Angela M Williams, Molly M McGinnis and Brendan M Walker

Neuropsychopharmacology (New York, N.Y.), Vol.38(4), pp.647-654

03/2013

DOI: https://doi.org/10.1038/npp.2012.229

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https://hdl.handle.net/2376/109356

PMCID: PMC3572461

PMID: 23212453

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Abstract

operant self-administration

Alcohol & Alcoholism

Kappa Opioid Receptor

negative affect

alcohol and alcoholism

cues

kappa-opioid receptor

Mood

Psychopharmacology

Dynorphin

Opioids

Anxiety

Self-Administration

ultrasonic vocalizations

Original

Stress Disorders

Negative affect promotes dysregulated alcohol consumption in non-dependent and alcohol-dependent animals, and cues associated with negative affective states induce withdrawal-like symptoms in rats. This study was designed to test the hypotheses that: (1) the kappa-opioid receptor (KOR) system mediates phenotypes related to alcohol withdrawal and withdrawal-like negative affective states and (2) cues associated with negative affective states would result in dysregulated alcohol consumption when subsequently presented alone. To accomplish these goals, intracerebroventricular infusion of the KOR antagonist nor-binaltorphimine (nor-BNI) was assessed for the ability to attenuate the increase in 22-kHz ultrasonic vocalizations (USVs) associated with alcohol withdrawal and KOR activation in adult male wistar rats. Furthermore, cues associated with a KOR agonist-induced negative affective state were assessed for the ability to dysregulate alcohol consumption and the efficacy of intracerebroventricular KOR antagonism to reduce such dysregulation was evaluated. KOR antagonism blocked the increased number of 22-kHz USVs observed during acute alcohol withdrawal and a KOR agonist (U50,488) resulted in a nor-BNI reversible increase in 22-kHz USVs (mimicking an alcohol-dependent state). Additionally, cues associated with negative affective states resulted in escalated alcohol self-administration, an effect that was nor-BNI sensitive. Taken together, this study implicates negative affective states induced by both alcohol withdrawal and conditioned stimuli as being produced, in part, by activity of the DYN/KOR system.

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Title: Affective Cue-Induced Escalation of Alcohol Self-Administration and Increased 22-kHz Ultrasonic Vocalizations during Alcohol Withdrawal: Role of Kappa-Opioid Receptors
Creators: Anthony L Berger - , Pullman, WA
Angela M Williams - , Pullman, WA
Molly M McGinnis - , Pullman, WA
Brendan M Walker - , Pullman, WA
Publication Details: Neuropsychopharmacology (New York, N.Y.), Vol.38(4), pp.647-654
Academic Unit: Integrative Physiology and Neuroscience, Department of
Publisher: Nature Publishing Group
Identifiers: 99900547157901842
Language: English
Resource Type: Journal article