Journal article
Age-related innate immune response in calves to Babesia bovis involves IL-12 induction and IL-10 modulation
Annals of the New York Academy of Sciences, Vol.969(1), pp.164-168
10/2002
Handle:
https://hdl.handle.net/2376/104404
PMID: 12381584
Abstract
There is a strong innate immunity in calves to infection with Babesia bovis. Interleukin (IL)-12 and IL-10 have been shown in vitro to be important immunoregulatory cytokines. Here we demonstrate in vivo that the protective innate response in young calves to infection with virulent B. bovis involves the early appearance of IL-12 and interferon-gamma (IFN-gamma) transcripts in the spleen. In contrast, IL-12 and IFN-gamma mRNA expression in the spleens of adult cattle that succumbed to the infection was delayed and depressed and occurred within the context of IL-10 expression. Also in contrast with calves, there was no detectable antibody response before death in adults. A vigorous CD8+ T-cell expansion occurred in the spleens of both calves and adults.
Metrics
10 Record Views
Details
- Title
- Age-related innate immune response in calves to Babesia bovis involves IL-12 induction and IL-10 modulation
- Creators
- W L Goff - Animal Diseases Research Unit, USDA-ARS, Pullman, Washington 99164, USA. wgoff@vetmed.wsu.eduW C JohnsonW TuoR A ValdezS M ParishG M BarringtonW C Davis
- Publication Details
- Annals of the New York Academy of Sciences, Vol.969(1), pp.164-168
- Academic Unit
- Veterinary Microbiology and Pathology, Department of
- Publisher
- United States
- Identifiers
- 99900546825401842
- Language
- English
- Resource Type
- Journal article