Journal article
Alcohol drinking in never users of tobacco, cigarette smoking in never drinkers, and the risk of head and neck cancer: pooled analysis in the International Head and Neck Cancer Epidemiology Consortium
JNCI : Journal of the National Cancer Institute, Vol.99(10), pp.777-789
05/16/2007
Handle:
https://hdl.handle.net/2376/111962
PMID: 17505073
Abstract
At least 75% of head and neck cancers are attributable to a combination of cigarette smoking and alcohol drinking. A precise understanding of the independent association of each of these factors in the absence of the other with the risk of head and neck cancer is needed to elucidate mechanisms of head and neck carcinogenesis and to assess the efficacy of interventions aimed at controlling either risk factor.
We examined the extent to which head and neck cancer is associated with cigarette smoking among never drinkers and with alcohol drinking among never users of tobacco. We pooled individual-level data from 15 case-control studies that included 10,244 head and neck cancer case subjects and 15,227 control subjects, of whom 1072 case subjects and 5775 control subjects were never users of tobacco and 1598 case subjects and 4051 control subjects were never drinkers of alcohol. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using unconditional logistic regression models. All statistical tests were two-sided.
Among never drinkers, cigarette smoking was associated with an increased risk of head and neck cancer (OR for ever versus never smoking = 2.13, 95% CI = 1.52 to 2.98), and there were clear dose-response relationships for the frequency, duration, and number of pack-years of cigarette smoking. Approximately 24% (95% CI = 16% to 31%) of head and neck cancer cases among nondrinkers in this study would have been prevented if these individuals had not smoked cigarettes. Among never users of tobacco, alcohol consumption was associated with an increased risk of head and neck cancer only when alcohol was consumed at high frequency (OR for three or more drinks per day versus never drinking = 2.04, 95% CI = 1.29 to 3.21). The association with high-frequency alcohol intake was limited to cancers of the oropharynx/hypopharynx and larynx.
Our results represent the most precise estimates available of the independent association of each of the two main risk factors of head and neck cancer, and they exemplify the strengths of large-scale consortia in cancer epidemiology.
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Details
- Title
- Alcohol drinking in never users of tobacco, cigarette smoking in never drinkers, and the risk of head and neck cancer: pooled analysis in the International Head and Neck Cancer Epidemiology Consortium
- Creators
- Mia Hashibe - Gene-Environment Epidemiology Group, International Agency for Research on Cancer, 150 cours Albert Thomas, 69008 Lyon, France. hashibe@iarc.frPaul BrennanSimone BenhamouXavier CastellsagueChu ChenMaria Paula CuradoLuigino Dal MasoAlexander W DaudtEleonora FabianovaLeticia FernandezVictor Wünsch-FilhoSilvia FranceschiRichard B HayesRolando HerreroSergio KoifmanCarlo La VecchiaPhilip LazarusFabio LeviDana MatesElena MatosAna MenezesJoshua MuscatJose Eluf-NetoAndrew F OlshanPeter RudnaiStephen M SchwartzElaine SmithErich M SturgisNeonilia Szeszenia-DabrowskaRenato TalaminiQingyi WeiDeborah M WinnDavid ZaridzeWitold ZatonskiZuo-Feng ZhangJulien BerthillerPaolo Boffetta
- Publication Details
- JNCI : Journal of the National Cancer Institute, Vol.99(10), pp.777-789
- Academic Unit
- Department of Pharmaceutical Sciences
- Publisher
- United States
- Grant note
- R03CA77954 / NCI NIH HHS T32 CA009142 / NCI NIH HHS TW01500 / FIC NIH HHS P30ES010126 / NIEHS NIH HHS R01DE11979 / NIDCR NIH HHS R03CA113157 / NCI NIH HHS R01DE13110 / NIDCR NIH HHS R21ES011667 / NIEHS NIH HHS U01CA96134 / NCI NIH HHS T32CA09142 / NCI NIH HHS P01CA068384 / NCI NIH HHS K07CA104231 / NCI NIH HHS R01CA048896 / NCI NIH HHS R01ES11740 / NIEHS NIH HHS R01CA61188 / NCI NIH HHS R01CA100264 / NCI NIH HHS R01DA11386 / NIDA NIH HHS P50CA90388 / NCI NIH HHS R01DE012609 / NIDCR NIH HHS
- Identifiers
- 99900547596001842
- Language
- English
- Resource Type
- Journal article