Journal article
Alcohol-induced plasticity in the dynorphin/kappa-opioid receptor system
Frontiers in molecular neuroscience, Vol.5(2012), pp.1-29
2012
Handle:
https://hdl.handle.net/2376/109085
PMCID: PMC3459013
PMID: 23060746
Abstract
Alcoholism is a chronic relapsing disorder characterized by continued alcohol use despite numerous adverse consequences. Alcohol has been shown to interact with numerous neurotransmitter systems to exert its pharmacological effects. The endogenous opioid system (EOS) has been strongly implicated in the positive and negative reinforcing effects of alcohol. Traditionally recognized as dysphoric/anhedonic in nature, the dynorphin/kappa-opioid receptor (DYN/KOR) system has recently received considerable attention due to evidence suggesting that an upregulated DYN/KOR system may be a critical contributor to the complex factors that result in escalated alcohol consumption once dependent. The present review will discuss alcohol-induced plasticity in the DYN/KOR system and how these neuroadaptations could contribute to excessive alcohol seeking and consumption.
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Details
- Title
- Alcohol-induced plasticity in the dynorphin/kappa-opioid receptor system
- Creators
- Sunil Sirohi - Laboratory of Alcoholism and Addictions Neuroscience, Department of Psychology, Washington State UniversityGeorgy Bakalkin - Division of Biological Research on Drug Dependence, Department of Pharmaceutical Biosciences, Uppsala UniversityBrendan M Walker - Laboratory of Alcoholism and Addictions Neuroscience, Department of Psychology, Washington State University
- Publication Details
- Frontiers in molecular neuroscience, Vol.5(2012), pp.1-29
- Academic Unit
- Integrative Physiology and Neuroscience, Department of
- Publisher
- Frontiers Media S.A
- Identifiers
- 99900547385701842
- Language
- English
- Resource Type
- Journal article