Altered Hematopoiesis, Behavior, and Sexual Function in μ Opioid Receptor–deficient Mice

Mingting Tian; Hal E Broxmeyer; Yi Fan; Zhennan Lai; Shengwen Zhang; Susan Aronica; Scott Cooper; Robert M Bigsby; Rosemary Steinmetz; Sandra J Engle; Anton Mestek; Jonathan D Pollock; Michael N Lehman; Heiko T Jansen; Moyin Ying; Peter J Stambrook; Jay A Tischfield; Lei Yu

doi:10.1084/jem.185.8.1517

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Altered Hematopoiesis, Behavior, and Sexual Function in μ Opioid Receptor–deficient Mice

Journal article

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Altered Hematopoiesis, Behavior, and Sexual Function in μ Opioid Receptor–deficient Mice

Mingting Tian, Hal E Broxmeyer, Yi Fan, Zhennan Lai, Shengwen Zhang, Susan Aronica, Scott Cooper, Robert M Bigsby, Rosemary Steinmetz, Sandra J Engle, …

The Journal of experimental medicine, Vol.185(8), pp.1517-1522

04/21/1997

DOI: https://doi.org/10.1084/jem.185.8.1517

Handle:

https://hdl.handle.net/2376/114797

PMCID: PMC2196276

PMID: 9126934

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https://doi.org/10.1084/jem.185.8.1517View

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Abstract

Brief Definitive Report

The μ opioid receptor is thought to be the cellular target of opioid narcotics such as morphine and heroin, mediating their effects in both pain relief and euphoria. Its involvement is also implicated in a range of diverse biological processes. Using a mouse model in which the receptor gene was disrupted by targeted homologous recombination, we explored the involvement of this receptor in a number of physiological functions. Mice homozygous for the disrupted gene developed normally, but their motor function was altered. Drug-naive homozygotes displayed reduced locomotor activity, and morphine did not induce changes in locomotor activity observed in wild-type mice. Unexpectedly, lack of a functional receptor resulted in changes in both the host defense system and the reproductive system. We observed increased proliferation of granulocyte-macrophage, erythroid, and multipotential progenitor cells in both bone marrow and spleen, indicating a link between hematopoiesis and the opioid system, both of which are stress-responsive systems. Unexpected changes in sexual function in male homozygotes were also observed, as shown by reduced mating activity, a decrease in sperm count and motility, and smaller litter size. Taken together, these results suggest a novel role of the μ opioid receptor in hematopoiesis and reproductive physiology, in addition to its known involvement in pain relief.

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Title: Altered Hematopoiesis, Behavior, and Sexual Function in μ Opioid Receptor–deficient Mice
Creators: Mingting Tian - From the
Hal E Broxmeyer - From the
Yi Fan - From the
Zhennan Lai - From the
Shengwen Zhang - From the
Susan Aronica - From the
Scott Cooper - From the
Robert M Bigsby - From the
Rosemary Steinmetz - From the
Sandra J Engle - From the
Anton Mestek - From the
Jonathan D Pollock - From the
Michael N Lehman - From the
Heiko T Jansen - From the
Moyin Ying - From the
Peter J Stambrook - From the
Jay A Tischfield - From the
Lei Yu - From the
Publication Details: The Journal of experimental medicine, Vol.185(8), pp.1517-1522
Academic Unit: Integrative Physiology and Neuroscience, Department of
Publisher: The Rockefeller University Press
Identifiers: 99900548319701842
Language: English
Resource Type: Journal article