Journal article
Altered Subthreshold Sodium Currents and Disrupted Firing Patterns in Purkinje Neurons of Scn8a Mutant Mice
Neuron (Cambridge, Mass.), Vol.19(4), pp.881-891
1997
Handle:
https://hdl.handle.net/2376/113911
PMID: 9354334
Abstract
Sodium currents and action potentials were characterized in Purkinje neurons from ataxic mice lacking expression of the sodium channel
Scn8a. Peak transient sodium current was ∼60% of that in normal mice, but subthreshold sodium current was affected much more. Steady-state current elicited by voltage ramps was reduced to ∼30%, and resurgent sodium current, an unusual transient current elicited on repolarization following strong depolarizations, was reduced to 8%–18%. In jolting mice, with a missense mutation in
Scn8a, steady-state and resurgent current were also reduced, with altered voltage dependence and kinetics. Both spontaneous firing and evoked bursts of spikes were diminished in cells from null and jolting mice. Evidently
Scn8a channels carry most subthreshold sodium current and are crucial for repetitive firing.
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Details
- Title
- Altered Subthreshold Sodium Currents and Disrupted Firing Patterns in Purkinje Neurons of Scn8a Mutant Mice
- Creators
- Indira M Raman - Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USALeslie K Sprunger - Department of Human Genetics, University of Michigan, Ann Arbor, Michigan 48109, USAMiriam H Meisler - Department of Human Genetics, University of Michigan, Ann Arbor, Michigan 48109, USABruce P Bean - Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
- Publication Details
- Neuron (Cambridge, Mass.), Vol.19(4), pp.881-891
- Publisher
- Elsevier Inc
- Identifiers
- 99900548240501842
- Language
- English
- Resource Type
- Journal article