Journal article
Alzheimer's Disease and Sleep-Wake Disturbances: Amyloid, Astrocytes, and Animal Models
The Journal of neuroscience, Vol.38(12), pp.2901-2910
03/21/2018
Handle:
https://hdl.handle.net/2376/116484
PMCID: PMC6596072
PMID: 29563238
Abstract
Sleep-wake abnormalities are common in patients with Alzheimer's disease, and can be a major reason for institutionalization. However, an emerging concept is that these sleep-wake disturbances are part of the causal pathway accelerating the neurodegenerative process. Recently, new findings have provided intriguing evidence for a positive feedback loop between sleep-wake dysfunction and β-amyloid (Aβ) aggregation. Studies in both humans and animal models have shown that extended periods of wakefulness increase Aβ levels and aggregation, and accumulation of Aβ causes fragmentation of sleep. This perspective is aimed at presenting evidence supporting causal links between sleep-wake dysfunction and aggregation of Aβ peptide in Alzheimer's disease, and explores the role of astrocytes, a specialized type of glial cell, in this context underlying Alzheimer's disease pathology. The utility of current animal models and the unexplored potential of alternative animal models for testing mechanisms involved in the reciprocal relationship between sleep disruption and Aβ are also discussed.
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Details
- Title
- Alzheimer's Disease and Sleep-Wake Disturbances: Amyloid, Astrocytes, and Animal Models
- Creators
- William M Vanderheyden - Elson S. Floyd College of Medicine, Washington State University, Spokane, Washington 99202Miranda M Lim - Oregon Health & Science University, Portland, Oregon 97239, andErik S Musiek - Department of Neurology, Washington University School of Medicine, St. Louis, Missouri 63110Jason R Gerstner - Elson S. Floyd College of Medicine, Washington State University, Spokane, Washington 99202, j.gerstner@wsu.edu
- Publication Details
- The Journal of neuroscience, Vol.38(12), pp.2901-2910
- Academic Unit
- Biomedical Sciences, Department of
- Publisher
- United States
- Identifiers
- 99900548148801842
- Language
- English
- Resource Type
- Journal article