Journal article
An IL-1 receptor and an IL-1 receptor antagonist attenuate muramyl dipeptide- and IL-1-induced sleep and fever
American journal of physiology. Regulatory, integrative and comparative physiology, Vol.265(4), pp.R907-R913
10/01/1993
Handle:
https://hdl.handle.net/2376/109867
PMID: 8238464
Abstract
It is hypothesized that the somnogenic and pyrogenic effects of muramyl dipeptide (MDP) are mediated via enhanced interleukin-1 (IL-1) production. To test this hypothesis the effects of intracerebroventricular (icv) administration of a recombinant human soluble type I IL-1 receptor (sIL-1r) and of the IL-1 receptor antagonist (IL-1ra) on MDP-induced sleep and fever were evaluated in rabbits. The sIL-1r recognized rabbit IL-1 beta, but it did not affect sleep or brain temperature across the dose range tested (1-50 micrograms) when injected icv into normal rabbits. Pretreatment of rabbits with 50 micrograms sIL-1r or 10 micrograms IL-1ra blocked human recombinant IL-1-enhanced nonrapid eye movement (NREM) sleep and fever. Thus both the sIL-1r and the IL-1ra were effective antagonists of IL-1 actions. When the animals were pretreated with either 50 micrograms sIL-1r or with 10 or 100 micrograms of the IL-1ra, the somnogenic effects of 150 pmol MDP were attenuated. However, the sIL-1r had little effect on MDP-induced febrile responses. These results suggest that the sIL-1r and the IL-1ra can function as antagonists of IL-1 actions in vivo and that MDP-induced sleep and fever are partially mediated by IL-1.
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Details
- Title
- An IL-1 receptor and an IL-1 receptor antagonist attenuate muramyl dipeptide- and IL-1-induced sleep and fever
- Creators
- L Imeri - Department of Physiology and Biophysics, University of Tennessee,Memphis 38163M. R Opp - Department of Physiology and Biophysics, University of Tennessee,Memphis 38163J. M Krueger - Department of Physiology and Biophysics, University of Tennessee,Memphis 38163
- Publication Details
- American journal of physiology. Regulatory, integrative and comparative physiology, Vol.265(4), pp.R907-R913
- Academic Unit
- Integrative Physiology and Neuroscience, Department of
- Identifiers
- 99900547138301842
- Language
- English
- Resource Type
- Journal article