Journal article
An anti-tumor necrosis factor antibody suppresses sleep in rats and rabbits
Brain research, Vol.690(2), pp.241-244
1995
Handle:
https://hdl.handle.net/2376/100414
PMID: 8535843
Abstract
It is hypothesized that tumor necrosis factor (TNF) is an endogenous sleep-promoting substance. In the present experiments we studied the effects of a monoclonal anti-TNF antibody in rats and rabbits. Seven rats and 14 rabbits were implanted with electroencephalographic electrodes, a brain thermistor and an intracerebroventricular guide cannula. The animals were injected with saline, control IgG, and monoclonal hamster anti-murine-TNF antibodies (TNFab) on 3 separate days. Ten μg TNFab suppressed non-rapid-eye-movement sleep (NREMS) in rats. In rabbits, 2.5 μg TNFab did not affect sleep but decreased brain temperature; in contrast, 25 μg TNFab suppressed NREMS without affecting brain temperature. These results are consistent with the hypothesis that endogenous TNF plays an important role in sleep regulation.
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Details
- Title
- An anti-tumor necrosis factor antibody suppresses sleep in rats and rabbits
- Creators
- Satoshi TakahashiLevente Kapa´sJidong FangJames M Krueger
- Publication Details
- Brain research, Vol.690(2), pp.241-244
- Academic Unit
- Biomedical Sciences, Department of; Integrative Physiology and Neuroscience, Department of
- Publisher
- Elsevier B.V
- Identifiers
- 99900546544301842
- Language
- English
- Resource Type
- Journal article