An application of analyzing the trajectories of two disorders: A parallel piecewise growth model of substance use and attention-deficit/hyperactivity disorder

Mary Rose Mamey; Celestina Barbosa-Leiker; Sterling McPherson; G Leonard Burns; Craig Parks; John Roll

doi:10.1037/pha0000047

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An application of analyzing the trajectories of two disorders: A parallel piecewise growth model of substance use and attention-deficit/hyperactivity disorder

Journal article

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An application of analyzing the trajectories of two disorders: A parallel piecewise growth model of substance use and attention-deficit/hyperactivity disorder

Mary Rose Mamey, Celestina Barbosa-Leiker, Sterling McPherson, G Leonard Burns, Craig Parks and John Roll

Experimental and clinical psychopharmacology, Vol.23(6), pp.422-427

12/2015

DOI: https://doi.org/10.1037/pha0000047

Handle:

https://hdl.handle.net/2376/120903

PMCID: PMC4658254

PMID: 26389639

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Abstract

Adolescent

Attention Deficit Disorder with Hyperactivity - complications

Attention Deficit Disorder with Hyperactivity - diagnosis

Attention Deficit Disorder with Hyperactivity - drug therapy

Central Nervous System Stimulants - therapeutic use

Cognitive Therapy

Combined Modality Therapy

Disease Progression

Methylphenidate - therapeutic use

Models, Theoretical

Substance-Related Disorders - complications

Substance-Related Disorders - diagnosis

Substance-Related Disorders - therapy

Researchers often want to examine 2 comorbid conditions simultaneously. One strategy to do so is through the use of parallel latent growth curve modeling (LGCM). This statistical technique allows for the simultaneous evaluation of 2 disorders to determine the explanations and predictors of change over time. Additionally, a piecewise model can help identify whether there are more than 2 growth processes within each disorder (e.g., during a clinical trial). A parallel piecewise LGCM was applied to self-reported attention-deficit/hyperactivity disorder (ADHD) and self-reported substance use symptoms in 303 adolescents enrolled in cognitive-behavioral therapy treatment for a substance use disorder and receiving either oral-methylphenidate or placebo for ADHD across 16 weeks. Assessing these 2 disorders concurrently allowed us to determine whether elevated levels of 1 disorder predicted elevated levels or increased risk of the other disorder. First, a piecewise growth model measured ADHD and substance use separately. Next, a parallel piecewise LGCM was used to estimate the regressions across disorders to determine whether higher scores at baseline of the disorders (i.e., ADHD or substance use disorder) predicted rates of change in the related disorder. Finally, treatment was added to the model to predict change. While the analyses revealed no significant relationships across disorders, this study explains and applies a parallel piecewise growth model to examine the developmental processes of comorbid conditions over the course of a clinical trial. Strengths of piecewise and parallel LGCMs for other addictions researchers interested in examining dual processes over time are discussed.

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Title: An application of analyzing the trajectories of two disorders: A parallel piecewise growth model of substance use and attention-deficit/hyperactivity disorder
Creators: Mary Rose Mamey - Washington State University
Celestina Barbosa-Leiker - Washington State University
Sterling McPherson - Washington State University
G Leonard Burns - Washington State University
Craig Parks - Washington State University
John Roll - Washington State University
Publication Details: Experimental and clinical psychopharmacology, Vol.23(6), pp.422-427
Academic Unit: Psychology, Department of
Grant note: 5 U10 DA013714-10 / NIDA NIH HHS L30 DA038339 / NIDA NIH HHS UG1 DA013714 / NIDA NIH HHS U10 DA013714 / NIDA NIH HHS P30 DA016383 / NIDA NIH HHS P30DA016383 / NIDA NIH HHS
Identifiers: 99900631533801842
Language: English
Resource Type: Journal article