Journal article
An example of a two-part latent growth curve model for semicontinuous outcomes in the health sciences
Journal of applied statistics, Vol.39(10), pp.2113-2128
10/01/2012
Handle:
https://hdl.handle.net/2376/113087
Abstract
A new method of modeling coronary artery calcium (CAC) is needed in order to properly understand the probability of onset and growth of CAC. CAC remains a controversial indicator of cardiovascular disease (CVD) risk, but this may be due to ill-equipped methods of specifying CAC during the analysis phase of studies reporting an analysis where CAC is the primary outcome. The modern method of two-part latent growth modeling may represent a strong alternative to the myriad of existing methods for modeling CAC. We provide a brief overview of existing methods of analysis used for CAC before introducing the general latent growth curve model, how it extends into a two-part (semicontinuous) growth model, and how the ubiquitous problem of missing data can be effectively handled. We then present an example of how to model CAC using this framework. We demonstrate that utilizing this type of modeling strategy can result in traditional predictors of CAC (e.g. age, gender, and high-density lipoprotein cholesterol), exerting a different impact on the two different, yet simultaneous, operationalizations of CAC. This method of analyzing CAC could inform future analyses of CAC and inform subsequent discussions about the nature of its potential to inform long-term CVD risk and heart events.
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Details
- Title
- An example of a two-part latent growth curve model for semicontinuous outcomes in the health sciences
- Creators
- Sterling McPherson - College of Nursing , Washington State UniversityCelestina Barbosa-Leiker - College of Nursing , Washington State University
- Publication Details
- Journal of applied statistics, Vol.39(10), pp.2113-2128
- Academic Unit
- Nursing, College of; Medical Education and Clinical Science, Department of
- Publisher
- Taylor & Francis
- Identifiers
- 99900548104101842
- Language
- English
- Resource Type
- Journal article