Journal article
An interleukin-1 receptor fragment blocks ambient temperature-induced increases in brain temperature but not sleep in rabbits
Neuroscience letters, Vol.244(3), pp.125-128
1998
Handle:
https://hdl.handle.net/2376/112976
PMID: 9593505
Abstract
The effects of intracerebroventricular injection (i.c.v.) of an interleukin-1 (IL-1) inhibitor, a soluble IL-1 receptor fragment (IL-1RF), on sleep and brain temperature (T
br) responses of rabbits induced by mild increases in ambient temperature (T
amb) were determined. Each rabbit was recorded under three conditions: (1) 21°C T
amb plus pyrogen-free saline (PFS); (2) 27°C T
amb plus PFS; (3) 27°C T
amb plus the IL-1RF. The higher T
amb significantly increased T
br during the warming period; this effect was attenuated by pretreatment with the IL-1RF. The higher T
amb alone (6 h exposure) significantly increased non-rapid eye movement sleep (NREMS) across the 23-h recording period. However, during the 6-h warming period NREMS values, obtained after IL-1RF treatment, were not significantly different from those obtained from PFS-treated animals at 27°C T
amb. The ability of the IL-1RF to block T
amb-induced changes in T
br and the failure of the IL-1RF to block T
amb-induced NREMS responses is different from previous results which indicated that a tumor necrosis factor receptor fragment (TNF-RF) inhibits warm T
amb-induced sleep but not T
br responses. Thus, brain IL-1 and TNF sleep and thermo mechanisms are, in part, different.
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Details
- Title
- An interleukin-1 receptor fragment blocks ambient temperature-induced increases in brain temperature but not sleep in rabbits
- Creators
- Tetsuya Kushikata - Department of Veterinary and Comparative Anatomy, Pharmacology, and Physiology, Washington State University, Pullman, WA 99164-6520, USASatoshi Takahashi - Department of Anesthesiology, University of Hirosaki School of Medicine, Zaifu 5, Hirosaki, Japan 036Ying Wang - Department of Physiology and Biophysics, The University of Tennessee, Memphis, TN 38163, USAJidong Fang - Department of Veterinary and Comparative Anatomy, Pharmacology, and Physiology, Washington State University, Pullman, WA 99164-6520, USAJames M Krueger - Department of Veterinary and Comparative Anatomy, Pharmacology, and Physiology, Washington State University, Pullman, WA 99164-6520, USA
- Publication Details
- Neuroscience letters, Vol.244(3), pp.125-128
- Academic Unit
- Integrative Physiology and Neuroscience, Department of
- Publisher
- Elsevier Ireland Ltd
- Identifiers
- 99900547752901842
- Language
- English
- Resource Type
- Journal article