Journal article
An interleukin-1 receptor fragment inhibits spontaneous sleep and muramyl dipeptide-induced sleep in rabbits
American journal of physiology. Regulatory, integrative and comparative physiology, Vol.271(1), pp.R101-R108
07/01/1996
Handle:
https://hdl.handle.net/2376/110619
PMID: 8760209
Abstract
Interleukin-1 (IL-1) is hypothesized to be involved in physiological sleep regulation and in sleep responses occurring during infectious disease. If this hypothesis is correct, then inhibition of endogenous IL-1 should reduce both normal sleep and N-acetylmuramyl-L-alanyl-D-isoglutamine (MDP)-induced sleep. MDP is a somnogenic substance derived from bacterial cell walls. We report here the effects of a synthetic IL-1 receptor fragment corresponding to amino acid residues 86-95 of the human type I IL-1 receptor (IL-1RF) on spontaneous sleep and IL-1 beta- and MDP-induced sleep and fever in rabbits. Two doses of the IL-1RF (25 and 50 micrograms) were injected into normal rabbits intracerebroventricularly (icv). Both doses significantly decreased spontaneous non-rapid eye movement sleep (NREMS) across a 22-h recording period. Pretreatment of rabbits with 25 micrograms of IL-1RF blocked the somnogenic actions of 10 ng icv IL-1. Similarly, central pretreatment of animals with 25 micrograms IL-1RF significantly attenuated the NREMS-promoting and REMS-suppressive actions of 150 pmol MDP injected centrally. The increase in NREMS and decrease in REMS induced by systemic injection of 12.5 micrograms/kg MDP were also significantly suppressed by central administration of 50 micrograms IL-1RF. In contrast, the febrile response induced by either intracerebroventricularly or intravenously injected MDP were not significantly affected by IL-1RF. These results support the hypothesis that endogenous, brain-derived IL-1 contributes to the maintenance of normal sleep and may mediate sleep responses to systemic as well as central bacterial infections.
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Details
- Title
- An interleukin-1 receptor fragment inhibits spontaneous sleep and muramyl dipeptide-induced sleep in rabbits
- Creators
- S Takahashi - Department of Physiology and Biophysics, University of Tennessee, Memphis 38163, USAL Kapas - Department of Physiology and Biophysics, University of Tennessee, Memphis 38163, USAJ Fang - Department of Physiology and Biophysics, University of Tennessee, Memphis 38163, USAJ. M Seyer - Department of Physiology and Biophysics, University of Tennessee, Memphis 38163, USAY Wang - Department of Physiology and Biophysics, University of Tennessee, Memphis 38163, USAJ. M Krueger - Department of Physiology and Biophysics, University of Tennessee, Memphis 38163, USA
- Publication Details
- American journal of physiology. Regulatory, integrative and comparative physiology, Vol.271(1), pp.R101-R108
- Academic Unit
- Biomedical Sciences, Department of; Integrative Physiology and Neuroscience, Department of
- Identifiers
- 99900547653401842
- Language
- English
- Resource Type
- Journal article