Journal article
An opioid basis for early-phase isoflurane-induced hypotension in rats
Life sciences (1973), Vol.73(20), pp.2591-2602
2003
Handle:
https://hdl.handle.net/2376/113309
PMID: 12967683
Abstract
This study was conducted to more clearly delineate the possible role of endogenous opioid receptors and opioid peptides in general anesthesia-associated hypotension in rats. Exposure to 2% isoflurane in oxygen produced a triphasic change in mean arterial pressure (MAP), including an early phase in which MAP fell by −28.4 ± 2.2%. The magnitude of this early-phase hypotension was attenuated in rats pretreated with intravenous (i.v.) μ-subtype-selective doses of either naloxone or methylnaloxone but not central doses of the selective μ-opioid antagonist β-funaltrexamine. This early hypotensive phase was also reduced following i.v. pretreatment with antiserum against methionine-enkephalin but not β-endorphin. These findings suggest that early-phase isoflurane-induced hypotension may be due to activation of peripheral μ-opioid receptors by an endogenous opioid peptide, possibly related to methionine-enkephalin.
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Details
- Title
- An opioid basis for early-phase isoflurane-induced hypotension in rats
- Creators
- Elizabeth A Ellenberger - Department of Biomedical Sciences, University of Illinois College of Medicine at Rockford, Rockford, IL 61107, USAHeather L Lucas - Department of Biomedical Sciences, University of Illinois College of Medicine at Rockford, Rockford, IL 61107, USAJohn M Russo - Department of Biomedical Sciences, University of Illinois College of Medicine at Rockford, Rockford, IL 61107, USAJanet L Mueller - Department of Biomedical Sciences, University of Illinois College of Medicine at Rockford, Rockford, IL 61107, USAPeggy L Barrington - Department of Biomedical Sciences, University of Illinois College of Medicine at Rockford, Rockford, IL 61107, USALeon F Tseng - Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI 53226, USARaymond M Quock - Department of Biomedical Sciences, University of Illinois College of Medicine at Rockford, Rockford, IL 61107, USA
- Publication Details
- Life sciences (1973), Vol.73(20), pp.2591-2602
- Academic Unit
- Psychology, Department of
- Publisher
- Elsevier Inc
- Identifiers
- 99900547938001842
- Language
- English
- Resource Type
- Journal article