Journal article
An ultra low-cost smartphone device for in-situ monitoring of acute organophosphorus poisoning for agricultural workers
Sensors and actuators. B, Chemical, Vol.275, pp.300-305
12/01/2018
PMID: 37576435
Abstract
A smartphone based optical spectrum detection device with novel lens-less design.•High accuracy and high sensitivity for IL-6 biomarker detection and spiked organophosphorus poisoning sample diagnosis.•Assessment of the device for organophosphorus poisoning with blood samples from agricultural workers.•The results showed good agreement with that of conventional laboratory equipment.
In this work, we present an ultra-low-cost smartphone device for in situ quantification of OP poisoning severity. The performance of the lens-less smartphone spectrum apparatus (LeSSA) is evaluated using standard human Interleukin-6 (IL-6) immunoassay kits. Upon dose-response curve fitting, LeSSA demonstrates an accuracy of 99.5%. The limit of detection (LOD) of LeSSA was evaluated through comparison of 6.4 pg/ml with standard laboratory grade UV–vis spectrophotometer at 5.5 pg/ml. Evaluating the capacity of LeSSA in spike solution by combining plasma cholinesterase (PChE) and human plasma shows consistency at agreement of 97.6% between LeSSA and the laboratory instrument. For application demonstration, the activity of PChE for 24 agricultural workers’ plasma samples was measured with LeSSA, showing exceptional agreement (r2 = 0.92) with the laboratory instrument reference. In addition to near laboratory grade accuracy, the total manufacturing cost of LeSSA is only $20 USD highlighting it’s affordability. With LeSSA, clinicians can evaluate OP poisoning severity without the need to transport patient samples to facilities at far distances. Utilizing LeSSA, immediate results can be used for administration of appropriate treatment.
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Details
- Title
- An ultra low-cost smartphone device for in-situ monitoring of acute organophosphorus poisoning for agricultural workers
- Creators
- Yu-Chung Chang - School of Mechanical and Materials Engineering, Washington State University, Pullman, WA 99164, USAXiaoxiao Ge - Washington State UniversityLi-Ju Wang - School of Mechanical and Materials Engineering, Washington State University, Pullman, WA 99164, USAStephen Sauchi Lee - University of IdahoMichael H. Paulsen - University of WashingtonQaiser M. Khan - National Institute for Biotechnology and Genetic EngineeringZafar M. Khalid - National Institute for Biotechnology and Genetic EngineeringJaved A. Bhalli - National Institute for Biotechnology and Genetic EngineeringUsman Waheed - National Institute for Biotechnology and Genetic EngineeringChristopher D. Simpson - University of WashingtonDan Du - Washington State UniversityLei Li - Washington State UniversityYuehe Lin - Washington State University
- Publication Details
- Sensors and actuators. B, Chemical, Vol.275, pp.300-305
- Academic Unit
- School of Mechanical and Materials Engineering
- Publisher
- Elsevier B.V
- Number of pages
- 6
- Identifiers
- 99901227851201842
- Language
- English
- Resource Type
- Journal article