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An unexpected Bis-ligation of S-nitrosothiols
Journal article

An unexpected Bis-ligation of S-nitrosothiols

Jiming Zhang, Hua Wang and Ming Xian
Journal of the American Chemical Society, Vol.131(11), pp.3854-3855
03/25/2009
Handle:
https://hdl.handle.net/2376/108597
PMID: 19256495

Abstract

S-Nitrosothiols - chemistry Disulfides Proteins - chemistry Imino Acids Nitrosation Methods Phosphoranes
A bis-ligation reaction of S-nitrosothiols using triaryl substituted phosphine-thioester substrates has been developed. This reaction converts unstable primary S-nitrosothiols to stable disulfide-iminophosphorane products in high yields under mild conditions. It can potentially be applied for the detection of S-nitrosation in protein systems.

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