Journal article
Analysis of opioid efficacy, tolerance, addiction and dependence from cell culture to human
British journal of pharmacology, Vol.164(4), pp.1322-1334
10/2011
Handle:
https://hdl.handle.net/2376/106909
PMCID: PMC3229764
PMID: 21434879
Abstract
Opioid agonists are the most effective treatment for pain, but their use is limited by side effects, tolerance and fears of addiction and dependence. A major goal of opioid research is to develop agonists that have high analgesic efficacy and a low profile for side effects, tolerance, addiction and dependence. Unfortunately, there is a serious lack of experimental data comparing the degree to which different opioids produce these effects in humans. In contrast, a wide range of experimental techniques from heterologous expression systems to behaviour assessment in whole animals have been developed to study these problems. The objective of this review is to describe and evaluate these techniques as they are used to study opioid efficacy, tolerance, addiction and dependence.
Metrics
4 Record Views
Details
- Title
- Analysis of opioid efficacy, tolerance, addiction and dependence from cell culture to human
- Creators
- Michael M Morgan - Department of Psychology, Washington State University Vancouver, Vancouver, WA, USAMacDonald J Christie
- Publication Details
- British journal of pharmacology, Vol.164(4), pp.1322-1334
- Academic Unit
- Psychology, Department of
- Publisher
- England
- Grant note
- R01 DA015498 / NIDA NIH HHS DA015498 / NIDA NIH HHS
- Identifiers
- 99900546555801842
- Language
- English
- Resource Type
- Journal article