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Analysis of the Anaplasma marginale major surface protein 1 complex protein composition by tandem mass spectrometry
Journal article   Open access  Peer reviewed

Analysis of the Anaplasma marginale major surface protein 1 complex protein composition by tandem mass spectrometry

Henriette Macmillan, Kelly A Brayton, Guy H Palmer, Travis C McGuire, Gerhard Munske, William F Siems and Wendy C Brown
Journal of bacteriology, Vol.188(13), pp.4983-4991
07/2006
DOI: https://doi.org/10.1128/JB.00170-06
Handle:
https://hdl.handle.net/2376/108561
PMCID: PMC1483013
PMID: 16788207
url
https://doi.org/10.1128/JB.00170-06View
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Abstract

Amino Acid Sequence Genes, Bacterial Multigene Family Anaplasma marginale - genetics Bacterial Outer Membrane Proteins - analysis Molecular Sequence Data Anaplasmosis - microbiology Animals Cattle Base Sequence Mass Spectrometry Chromatography, Liquid Anaplasma marginale - chemistry Bacterial Outer Membrane Proteins - genetics
The protective major surface protein 1 (MSP1) complex of Anaplasma marginale is a heteromer of MSP1a and MSP1b, encoded by a multigene family. The msp1beta sequences were highly conserved throughout infection. However, liquid chromatography-tandem mass spectrometry analysis identified only a single MSP1b protein, MSP1b1, within the MSP1 complex.

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