Journal article
Androgen effects on plasma GH, IGF-I, and 41-kDa IGFBP in coho salmon ( Oncorhynchus kisutch)
General and comparative endocrinology, Vol.139(1), pp.29-37
2004
Handle:
https://hdl.handle.net/2376/109194
PMID: 15474533
Abstract
Among many species of salmonids, fast growing fish mature earlier than slow growing fish, and maturing males grow faster than non-maturing ones. To study the potential endocrine basis for this reciprocal relationship we examined the in vivo effects of the androgens, testosterone (T) and 11-ketotestosterone (11-KT), on plasma growth hormone (GH), insulin-like growth factor-I (IGF-I) and 41-kDa IGF binding protein (41-kDa IGFBP) (putative IGFBP-3) in coho salmon,
Oncorhynchus kisutch. Immature male and female, two-year old fish (avg. wt. 31.7
±
0.63
g) were injected with coconut oil containing T or 11-KT at a dose of 0.1, 0.25, or 1
μg/g body weight. Blood samples were taken 1 and 2 weeks postinjection, and analyzed by immunoassay for T, 11-KT, GH, IGF-I, and 41-kDa IGFBP. Steroid treatments elevated the plasma T and 11-KT levels to physiological ranges typical of maturing fish. Plasma IGF-I and 41-kDa IGFBP levels increased in response to both T and 11-KT in a significant and dose-dependent manner after 1 and 2 weeks, but GH levels were not altered. These data suggest that during reproductive maturation, in addition to the previously demonstrated effects of the IGFs on steroidogenesis, the gonadal steroids may in turn play a significant role in regulating IGF-I and its binding proteins in fish. The interaction between the reproductive and growth axes may provide a regulatory mechanism for bringing about the dimorphic growth patterns observed between maturing and non-maturing salmonids and other species of fish.
Metrics
11 Record Views
Details
- Title
- Androgen effects on plasma GH, IGF-I, and 41-kDa IGFBP in coho salmon ( Oncorhynchus kisutch)
- Creators
- Donald A Larsen - Integrative Fish Biology Program, Northwest Fisheries Science Center, NOAA Fisheries, 2725 Montlake Blvd. E., Seattle, Washington 98112, USAMunetaka Shimizu - Integrative Fish Biology Program, Northwest Fisheries Science Center, NOAA Fisheries, 2725 Montlake Blvd. E., Seattle, Washington 98112, USAKathleen A Cooper - School of Aquatic and Fisheries Science, University of Washington, Seattle, Washington 98195, USAPenny Swanson - Integrative Fish Biology Program, Northwest Fisheries Science Center, NOAA Fisheries, 2725 Montlake Blvd. E., Seattle, Washington 98112, USAWalton W Dickhoff - Integrative Fish Biology Program, Northwest Fisheries Science Center, NOAA Fisheries, 2725 Montlake Blvd. E., Seattle, Washington 98112, USA
- Publication Details
- General and comparative endocrinology, Vol.139(1), pp.29-37
- Academic Unit
- UNKNOWN
- Publisher
- Elsevier Inc
- Identifiers
- 99900547186801842
- Language
- English
- Resource Type
- Journal article