Journal article
Angiotensin II(3–8) (ANG IV) hippocampal binding: Potential role in the facilitation of memory
Brain research bulletin, Vol.32(5), pp.497-502
1993
Handle:
https://hdl.handle.net/2376/106359
PMID: 8221142
Abstract
The present research characterizes a newly discovered ANG II(3–8) (ANG IV) binding site localized in structures associated with memory function (hippocampus, neocortex, cerebellum), as well as other brain stem structures (thalamus, inferior olivary nucleus). This site is not the AT
1 or AT
2 site that binds angiotensins II (ANG II) and III (ANG III) nor does it bind the nonpeptide AT
1 or AT
2 receptor antagonists DuP753 and PD123177, respectively. The intracerebroventricular (ICV) infusion of ANG IV was ineffective at inducing drinking in rats as compared with equivalent doses of ANG II and III. Although not as effective as ANG II or ANG III, ICV infusion of ANG IV did provoke a pressor response at the highest dose (100 pmol/min), which appeared to be mediated by ANG II (AT
1)-type receptors and not the specific AIV binding site described here. By contrast, the ICV infusion of ANG IV resulted in greater effects upon retention and retrieval of a passive avoidance task as compared with ANG II. Specifically, ANG II was not different from the ICV infusion of artificial cerebrospinal fluid, while ANG IV improved retention and retrieval of this task.
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Details
- Title
- Angiotensin II(3–8) (ANG IV) hippocampal binding: Potential role in the facilitation of memory
- Creators
- J.W Wright - Department of Psychology, Washington State University, Pullman, WA 99164-4820 USAA.V Miller-Wing - Department of Veterinary Comparative Anatomy, Pharmacology, and Physiology, Washington State University, Pullman, WA 99164-4820 USAM.J Shaffer - Department of Psychology, Washington State University, Pullman, WA 99164-4820 USAC Higginson - Department of Psychology, Washington State University, Pullman, WA 99164-4820 USAD.E Wright - Disabled Student Services, Washington State University, Pullman, WA 99164-4820 USAJ.M Hanesworth - Department of Veterinary Comparative Anatomy, Pharmacology, and Physiology, Washington State University, Pullman, WA 99164-4820 USAJ.W Harding - Department of Psychology, Washington State University, Pullman, WA 99164-4820 USA
- Publication Details
- Brain research bulletin, Vol.32(5), pp.497-502
- Academic Unit
- Psychology, Department of; Integrative Physiology and Neuroscience, Department of
- Publisher
- Elsevier Inc
- Identifiers
- 99900546753901842
- Language
- English
- Resource Type
- Journal article