Journal article
Angiotensin IV inhibits neurite outgrowth in cultured embryonic chicken sympathetic neurones
Brain research, Vol.725(1), pp.61-66
1996
Handle:
https://hdl.handle.net/2376/117988
PMID: 8828586
Abstract
Angiotensin IV (Val-Tyr-Ile-His-Pro-Phe) is reported to enhance apomorphine induced stereotypy and to improve memory recall through actions on specific binding sites in the central nervous system.
In the present study, 10 nM angiotensin IV or angiotensin II inhibited neurite outgrowth from cultured E11 chicken paravertebral sympathetic neurones by 25%. The effects of both peptides were inhibited by a 1 μM concentration of the angiotensin IV analogues, WSU 4042, Nle
1-Y-I-amide or Nle
1-AIV, but not by the avian angiotensin II antagonists, [Sar
1,Ile
8]Ang II or CGP 42112, suggesting that the inhibition of neurite outgrowth by both peptides is mediated by the angiotensin IV binding site.
These results suggest that angiotensin IV may be involved in neurite modelling and may therefore have an important role in neuronal development.
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Details
- Title
- Angiotensin IV inhibits neurite outgrowth in cultured embryonic chicken sympathetic neurones
- Creators
- Ingrid Moeller - Austin and Repatriation Medical Centre, Department of Medicine, University of Melbourne, Heidelberg, Victoria 3084, AustraliaDavid H Small - Laboratory of Molecular Neurobiology, Melbourne Nerve Growth Research Unit, Department of Pathology, University of Melbourne, Parkville, Victoria 3052, AustraliaGullveig Reed - Laboratory of Molecular Neurobiology, Melbourne Nerve Growth Research Unit, Department of Pathology, University of Melbourne, Parkville, Victoria 3052, AustraliaJoseph W Harding - Department of VCAPP, Washington State University, Pullman, WA, USAFrederick A.O Mendelsohn - Austin and Repatriation Medical Centre, Department of Medicine, University of Melbourne, Heidelberg, Victoria 3084, AustraliaSiew Yeen Chai - Austin and Repatriation Medical Centre, Department of Medicine, University of Melbourne, Heidelberg, Victoria 3084, Australia
- Publication Details
- Brain research, Vol.725(1), pp.61-66
- Academic Unit
- Integrative Physiology and Neuroscience, Department of
- Publisher
- Elsevier B.V
- Identifiers
- 99900548481701842
- Language
- English
- Resource Type
- Journal article