Angiotensin receptor subtype mediated physiologies and behaviors: new discoveries and clinical targets

John W Wright; Brent J Yamamoto; Joseph W Harding

doi:10.1016/j.pneurobio.2007.10.009

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Angiotensin receptor subtype mediated physiologies and behaviors: new discoveries and clinical targets

Journal article

Open access

Peer reviewed

Angiotensin receptor subtype mediated physiologies and behaviors: new discoveries and clinical targets

John W Wright, Brent J Yamamoto and Joseph W Harding

Progress in neurobiology, Vol.84(2), pp.157-181

02/2008

DOI: https://doi.org/10.1016/j.pneurobio.2007.10.009

Handle:

https://hdl.handle.net/2376/106431

PMCID: PMC2276843

PMID: 18160199

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Abstract

Renin-Angiotensin System - physiology

Animals

Receptors, Angiotensin - physiology

Humans

The renin-angiotensin system (RAS) mediates several classic physiologies including body water and electrolyte homeostasis, blood pressure, cyclicity of reproductive hormones and sexual behaviors, and the regulation of pituitary gland hormones. These functions appear to be mediated by the angiotensin II (AngII)/AT(1) receptor subtype system. More recently, the angiotensin IV (AngIV)/AT(4) receptor subtype system has been implicated in cognitive processing, cerebroprotection, local blood flow, stress, anxiety and depression. There is accumulating evidence to suggest an inhibitory influence by AngII acting at the AT(1) subtype, and a facilitory role by AngIV acting at the AT(4) subtype, on neuronal firing rate, long-term potentiation, associative and spatial learning, and memory. This review initially describes the biochemical pathways that permit synthesis and degradation of active angiotensin peptides and three receptor subtypes (AT(1), AT(2) and AT(4)) thus far characterized. There is vigorous debate concerning the identity of the most recently discovered receptor subtype, AT(4). Descriptions of classic and novel physiologies and behaviors controlled by the RAS are presented. This review concludes with a consideration of the emerging therapeutic applications suggested by these newly discovered functions of the RAS.

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Title: Angiotensin receptor subtype mediated physiologies and behaviors: new discoveries and clinical targets
Creators: John W Wright - Department of Psychology, Washington State University, P.O. Box 644820, Pullman, WA 99164-4820, USA. wrightw@wsu.edu
Brent J Yamamoto
Joseph W Harding
Publication Details: Progress in neurobiology, Vol.84(2), pp.157-181
Academic Unit: Psychology, Department of; Integrative Physiology and Neuroscience, Department of
Publisher: England
Grant note: R01 HL064245 / NHLBI NIH HHS R01-HL64245-03 / NHLBI NIH HHS R01 HL064245-03 / NHLBI NIH HHS
Identifiers: 99900546993401842
Language: English
Resource Type: Journal article