Journal article
Anion relay chemistry extended. Synthesis of a gorgonian sesquiterpene
Organic letters, Vol.9(17), pp.3307-3309
08/16/2007
Handle:
https://hdl.handle.net/2376/113050
PMID: 17637030
Abstract
Extension of anion relay chemistry (ARC) beyond the area of dithianes has been achieved by the design of two effective ARC linchpins capable of three- and four-component couplings. To showcase the ARC tactic in natural product synthesis, a cytotoxic gorgonian linear sesquiterpene was constructed, and the absolute configuration assigned via the Kakisawa/Mosher method. The synthesis proceeded in five steps with an overall yield of 22%.
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Details
- Title
- Anion relay chemistry extended. Synthesis of a gorgonian sesquiterpene
- Creators
- Amos B Smith, 3rd - Department of Chemistry, Monell Chemical Senses Center and Laboratory for Research on the Structure of Matter, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. smithab@sas.upenn.eduDae-Shik KimMing Xian
- Publication Details
- Organic letters, Vol.9(17), pp.3307-3309
- Academic Unit
- Chemistry, Department of
- Publisher
- United States
- Grant note
- GM-29028 / NIGMS NIH HHS
- Identifiers
- 99900547726501842
- Language
- English
- Resource Type
- Journal article