Journal article
Anomalous effects of losartan on aminopeptidase-induced reductions of blood pressure in SHR
Brain research bulletin, Vol.36(2), pp.169-174
1995
Handle:
https://hdl.handle.net/2376/115310
PMID: 7895095
Abstract
The present investigation initially determined that a commercially available aminopeptidase M (AmM, Sigma Chemical) can lower blood pressure when intracerebroventricularly (ICV) infused in spontaneously hypertensive rats (SHR). Pretreatment with the angiotensin II (Angll) receptor subtype 1 (AT
1) antagonist, DuP 753 (losartan) significantly attenuated this hypotensive effect, in a dose-dependent manner, while pretreatment with the Angll receptor subtype 2 (AT
2) antagonist, PD123177, did not influence AmM-induced hypotension. These results suggest that AT
1 receptors may be involved in the hypotension accompanying the ICV infusion of AmM; however, the relationship among available AT
1 sites, angiotensin ligands, and peptidase activity appears to be complicated with the likely involvement of additional, as yet unspecified, brain peptide systems possessing cardiovascular action.
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Details
- Title
- Anomalous effects of losartan on aminopeptidase-induced reductions of blood pressure in SHR
- Creators
- John W WrightTodd A HamiltonJoseph W Harding
- Publication Details
- Brain research bulletin, Vol.36(2), pp.169-174
- Academic Unit
- Psychology, Department of; Integrative Physiology and Neuroscience, Department of
- Publisher
- Elsevier Inc
- Identifiers
- 99900547751301842
- Language
- English
- Resource Type
- Journal article