Journal article
Antagonism of nitrous oxide antinociception in mice by antisense oligodeoxynucleotide directed against neuronal nitric oxide synthase enzyme
Behavioural brain research, Vol.152(2), pp.361-363
2004
Handle:
https://hdl.handle.net/2376/109024
PMID: 15196804
Abstract
Nitric oxide (NO) has been implicated in the antinociceptive effect of nitrous oxide (N
2O) in mice. This study was conducted to determine the sensitivity of N
2O-induced antinociception to antagonism by an antisense oligodeoxynucleotide (AS-ODN) against neuronal nitric oxide synthase (nNOS). The AS-ODN significantly antagonized the antinociceptive effect of N
2O in the abdominal constriction test, but a mismatch ODN was without effect. This result implicates the specific involvement of nNOS in N
2O-induced antinociception.
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Details
- Title
- Antagonism of nitrous oxide antinociception in mice by antisense oligodeoxynucleotide directed against neuronal nitric oxide synthase enzyme
- Creators
- Shuang Li - Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, P.O. Box 646534, Pullman, WA 99164-6534, USAAndrew J Bieber - Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, P.O. Box 646534, Pullman, WA 99164-6534, USARaymond M Quock - Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, P.O. Box 646534, Pullman, WA 99164-6534, USA
- Publication Details
- Behavioural brain research, Vol.152(2), pp.361-363
- Academic Unit
- Psychology, Department of
- Publisher
- Elsevier B.V
- Identifiers
- 99900547009201842
- Language
- English
- Resource Type
- Journal article