Journal article
Antibody escape kinetics of equine infectious anemia virus infection of horses
Journal of virology, Vol.89(13), pp.6945-6951
07/2015
Handle:
https://hdl.handle.net/2376/100503
PMCID: PMC4468492
PMID: 25878104
Abstract
Lentivirus escape from neutralizing antibodies (NAbs) is not well understood. In this work, we quantified antibody escape of a lentivirus, using antibody escape data from horses infected with equine infectious anemia virus. We calculated antibody blocking rates of wild-type virus, fitness costs of mutant virus, and growth rates of both viruses. These quantitative kinetic estimates of antibody escape are important for understanding lentiviral control by antibody neutralization and in developing NAb-eliciting vaccine strategies.
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Details
- Title
- Antibody escape kinetics of equine infectious anemia virus infection of horses
- Creators
- Elissa J Schwartz - School of Biological Sciences and Department of Mathematics, Washington State University, Pullman, Washington, USA ejs@wsu.edu nanda@math.tifrbng.res.inSeema Nanda - Centre for Applicable Mathematics, Tata Institute of Fundamental Research, Bangalore, India ejs@wsu.edu nanda@math.tifrbng.res.inRobert H Mealey - Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington, USA
- Publication Details
- Journal of virology, Vol.89(13), pp.6945-6951
- Academic Unit
- Veterinary Clinical Sciences, Department of; Biological Sciences, School of
- Publisher
- United States
- Identifiers
- 99900546520401842
- Language
- English
- Resource Type
- Journal article