Antibody response to a Babesia bigemina rhoptry-associated protein 1 surface-exposed and neutralization-sensitive epitope in immune cattle

T C Ushe; G H Palmer; L Sotomayor; J V Figueroa; G M Buening; L E Perryman; T F McElwain

doi:10.1128/IAI.62.12.5698-5701.1994

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Antibody response to a Babesia bigemina rhoptry-associated protein 1 surface-exposed and neutralization-sensitive epitope in immune cattle

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Peer reviewed

Antibody response to a Babesia bigemina rhoptry-associated protein 1 surface-exposed and neutralization-sensitive epitope in immune cattle

T C Ushe, G H Palmer, L Sotomayor, J V Figueroa, G M Buening, L E Perryman and T F McElwain

Infection and immunity, Vol.62(12), pp.5698-5701

12/1994

DOI: https://doi.org/10.1128/IAI.62.12.5698-5701.1994

Handle:

https://hdl.handle.net/2376/118358

PMCID: PMC303324

PMID: 7525490

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https://doi.org/10.1128/IAI.62.12.5698-5701.1994View

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Abstract

Cattle Diseases - prevention & control

Antigens, Protozoan - immunology

Species Specificity

Vaccination

Membrane Proteins - immunology

Neutralization Tests

Antibodies, Monoclonal

Cattle Diseases - immunology

Antibodies, Protozoan - biosynthesis

Epitopes - immunology

Animals

Babesiosis - immunology

Cattle

Babesiosis - prevention & control

Protozoan Proteins - immunology

Babesia - classification

Protective immunity against Babesia bigemina is hypothesized to involve antibodies directed against merozoite surface-exposed epitopes. Levels of antibody against a rhoptry-associated protein 1 (RAP-1) B-lymphocyte epitope, defined by surface-reactive and inhibitory monoclonal antibodies, in immune cattle sera were determined. All cattle produced antibodies to the epitope; however, there was limited correlation between immune protection induced by infection or RAP-1 immunization and the level of antibody to the neutralization-sensitive B-lymphocyte epitope examined.

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Title: Antibody response to a Babesia bigemina rhoptry-associated protein 1 surface-exposed and neutralization-sensitive epitope in immune cattle
Creators: T C Ushe - Department of Veterinary Microbiology and Pathology, Washington State University, Pullman 99164-7040
G H Palmer
L Sotomayor
J V Figueroa
G M Buening
L E Perryman
T F McElwain
Publication Details: Infection and immunity, Vol.62(12), pp.5698-5701
Academic Unit: Paul G. Allen School for Global Animal Health
Publisher: United States
Identifiers: 99900548088101842
Language: English
Resource Type: Journal article