Journal article
Antigenic Variation of Anaplasma marginale by Expression of MSP2 Mosaics
Infection and immunity, Vol.68(11), pp.6133-6138
11/2000
Handle:
https://hdl.handle.net/2376/116407
PMCID: PMC97690
PMID: 11035716
Abstract
Anaplasma marginale
is a tick-borne pathogen, one of several closely related ehrlichial organisms that cause disease in animals and humans. These
Ehrlichia
species have complex life cycles that require, in addition to replication and development within the tick vector, evasion of the immune system in order to persist in the mammalian reservoir host. This complexity requires efficient use of the small ehrlichial genome.
A. marginale
and related ehrlichiae express immunoprotective, variable outer membrane proteins that have similar structures and are encoded by polymorphic multigene families. We show here that the major outer membrane protein of
A. marginale
, MSP2, is encoded on a polycistronic mRNA. The genomic expression site for this mRNA is polymorphic and encodes numerous amino acid sequence variants in bloodstream populations of
A. marginale
. A potential mechanism for persistence is segmental gene conversion of the expression site to link hypervariable
msp2
sequences to the promoter and polycistron.
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Details
- Title
- Antigenic Variation of Anaplasma marginale by Expression of MSP2 Mosaics
- Creators
- Anthony F Barbet - Department of Pathobiology, College of Veterinary Medicine, University of Florida, Gainesville, Florida 32611-0880Anna Lundgren - Department of Pathobiology, College of Veterinary Medicine, University of Florida, Gainesville, Florida 32611-0880Jooyoung Yi - Department of Pathobiology, College of Veterinary Medicine, University of Florida, Gainesville, Florida 32611-0880Fred R Rurangirwa - Department of Pathobiology, College of Veterinary Medicine, University of Florida, Gainesville, Florida 32611-0880Guy H Palmer - Department of Pathobiology, College of Veterinary Medicine, University of Florida, Gainesville, Florida 32611-0880
- Publication Details
- Infection and immunity, Vol.68(11), pp.6133-6138
- Academic Unit
- Paul G. Allen School for Global Animal Health
- Publisher
- American Society for Microbiology
- Identifiers
- 99900547646201842
- Language
- English
- Resource Type
- Journal article