Journal article
Antimicrobial particulate silver coatings on stainless steel implants for fracture management
Materials Science & Engineering C, Vol.32(5), pp.1112-1120
07/01/2012
Handle:
https://hdl.handle.net/2376/108746
PMCID: PMC3375829
PMID: 22711980
Abstract
We have used particulate silver coating on stainless steel to prevent in vivo bacterial infection. Stainless steel is commonly used as an implant material for fracture management. The antimicrobial use of silver has been well documented and studied, therefore the novelty of this research is the use of a particulate coating as well as facing the real world challenges of a fracture repair implant. The variable parameters for applying the coating were time of deposition, silver solution concentration, voltage applied, heat treatment temperature between 400 and 500°C and time. The resultant coating is shown to be non-toxic to human osteoblasts using an MTT assay for proliferation and SEM images for morphology. In vitro silver release studies of various treatments were done using simulated body fluid. The bactericidal effects were tested by challenging the coatings with Pseudomonas aeruginosa in a bioreactor and compared against uncoated stainless steel. A 13-fold reduction in bacteria was observed at 24h and proved to be statistically significant.
► Processing of particulate silver coating that are strongly adherent on SS surface. ► Optimized the amount of silver that is sufficient to reduce bacterial colonization but non-toxic to human bone tissue. ► The adhesion strength of silver was sufficient to survive industrial sterilization steps used for fracture management devices.
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Details
- Title
- Antimicrobial particulate silver coatings on stainless steel implants for fracture management
- Creators
- Paul DeVasConCellos - W.M. Keck Biomedical Materials Research Laboratory, School of Mechanical and Materials Engineering, Washington State University, Pullman, WA, USASusmita Bose - W.M. Keck Biomedical Materials Research Laboratory, School of Mechanical and Materials Engineering, Washington State University, Pullman, WA, USAHaluk Beyenal - School of Chemical Engineering and Bioengineering, Washington State University, Pullman, WA, USAAmit Bandyopadhyay - W.M. Keck Biomedical Materials Research Laboratory, School of Mechanical and Materials Engineering, Washington State University, Pullman, WA, USALewis G Zirkle - Surgical Implant Generation Network (SIGN), Richland, WA, USA
- Publication Details
- Materials Science & Engineering C, Vol.32(5), pp.1112-1120
- Academic Unit
- Chemical Engineering and Bioengineering, School of; Mechanical and Materials Engineering, School of
- Publisher
- Elsevier B.V
- Identifiers
- 99900547369501842
- Language
- English
- Resource Type
- Journal article