Antimicrobial resistant enteric bacteria are widely distributed amongst people, animals and the environment in Tanzania

Murugan Subbiah; Mark A Caudell; Colette Mair; Margaret A Davis; Louise Matthews; Robert J Quinlan; Marsha B Quinlan; Beatus Lyimo; Joram Buza; Julius Keyyu; Douglas R Call

doi:10.1038/s41467-019-13995-5

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Antimicrobial resistant enteric bacteria are widely distributed amongst people, animals and the environment in Tanzania

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Antimicrobial resistant enteric bacteria are widely distributed amongst people, animals and the environment in Tanzania

Murugan Subbiah, Mark A Caudell, Colette Mair, Margaret A Davis, Louise Matthews, Robert J Quinlan, Marsha B Quinlan, Beatus Lyimo, Joram Buza, Julius Keyyu, …

Nature communications, Vol.11(1), pp.228-228

01/13/2020

DOI: https://doi.org/10.1038/s41467-019-13995-5

Handle:

https://hdl.handle.net/2376/117332

PMCID: PMC6957491

PMID: 31932601

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Abstract

Tanzania - epidemiology

Prevalence

Escherichia coli - drug effects

Humans

Bacteria - drug effects

Phylogeny

Escherichia coli Infections - ethnology

Microbial Sensitivity Tests

Feces - microbiology

Bacteria - classification

Drug Resistance, Bacterial - drug effects

Drug Resistance, Bacterial - genetics

Escherichia coli Infections - microbiology

Genotype

Gastrointestinal Microbiome - genetics

Bacteria - genetics

Escherichia coli Infections - epidemiology

Genome, Bacterial - genetics

Bacteria - isolation & purification

Animals

Escherichia coli - genetics

Escherichia coli - isolation & purification

Anti-Bacterial Agents - pharmacology

Escherichia coli - classification

Environmental Microbiology

Antibiotic use and bacterial transmission are responsible for the emergence, spread and persistence of antimicrobial-resistant (AR) bacteria, but their relative contribution likely differs across varying socio-economic, cultural, and ecological contexts. To better understand this interaction in a multi-cultural and resource-limited context, we examine the distribution of antimicrobial-resistant enteric bacteria from three ethnic groups in Tanzania. Household-level data (n = 425) was collected and bacteria isolated from people, livestock, dogs, wildlife and water sources (n = 62,376 isolates). The relative prevalence of different resistance phenotypes is similar across all sources. Multi-locus tandem repeat analysis (n = 719) and whole-genome sequencing (n = 816) of Escherichia coli demonstrate no evidence for host-population subdivision. Multivariate models show no evidence that veterinary antibiotic use increased the odds of detecting AR bacteria, whereas there is a strong association with livelihood factors related to bacterial transmission, demonstrating that to be effective, interventions need to accommodate different cultural practices and resource limitations.

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Title: Antimicrobial resistant enteric bacteria are widely distributed amongst people, animals and the environment in Tanzania
Creators: Murugan Subbiah - Paul G. Allen School for Global Animal Health, Washington State University, Pullman, WA, USA
Mark A Caudell - Food and Agriculture Organization of the United Nations, Nairobi, Kenya. mcaudell@wsu.edu
Colette Mair - Boyd Orr Centre for Population and Ecosystem Health, Institute of Biodiversity, Animal Health and Comparative Medicine, University of Glasgow, Glasgow, UK
Margaret A Davis - Paul G. Allen School for Global Animal Health, Washington State University, Pullman, WA, USA
Louise Matthews - Boyd Orr Centre for Population and Ecosystem Health, Institute of Biodiversity, Animal Health and Comparative Medicine, University of Glasgow, Glasgow, UK
Robert J Quinlan - Department of Anthropology, Washington State University, Pullman, WA, USA
Marsha B Quinlan - Department of Anthropology, Washington State University, Pullman, WA, USA
Beatus Lyimo - Nelson Mandela African Institution of Science and Technology, Arusha, Tanzania
Joram Buza - Nelson Mandela African Institution of Science and Technology, Arusha, Tanzania
Julius Keyyu - Tanzania Wildlife Research Institute, Arusha, Tanzania
Douglas R Call - Nelson Mandela African Institution of Science and Technology, Arusha, Tanzania
Publication Details: Nature communications, Vol.11(1), pp.228-228
Academic Unit: Anthropology, Department of
Grant note: BB/K01126X/1 / RCUK | Biotechnology and Biological Sciences Research Council (BBSRC) BB/L018926/1 / RCUK | Biotechnology and Biological Sciences Research Council (BBSRC)
Identifiers: 99900581051801842
Language: English
Resource Type: Journal article