Journal article
Antinociception mediated by the periaqueductal gray is attenuated by orphanin FQ
Neuroreport, Vol.8(16), pp.3431-3434
11/10/1997
Handle:
https://hdl.handle.net/2376/118343
PMID: 9427301
Abstract
ORPHANIN FQ or nociceptin (OFQ/N1-17) is a recently discovered peptide which, upon intracerebroventricular administration, reverses opioid-mediated analgesias. OFQ/N1-17 terminals are located in the periaqueductal gray (PAG), a structure known to be involved in pain modulation, suggesting that the functional anti-opioid effects of OFQ/N1-17 are mediated by PAG neurons. To test this, subsequent microinjections of morphine or kainic acid and OFQ/N1–17 were made into the PAG of awake rats. Administration of OFQ/N1–17 attenuated the tail flick inhibition produced by both morphine and kainic acid microinjection. OFQ/N1-17 attenuation of antinociception produced by a neuroexcitant indicates that OFQ/N1-17 reverses opioid antinociception by inhibiting PAG output neurons.
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Details
- Title
- Antinociception mediated by the periaqueductal gray is attenuated by orphanin FQ
- Creators
- Michael Morgan - 1Department of Psychology, Washington State University, 14204 NE Salmon Creek Avenue, Vancouver, WA 98686 2Department of Psychology, Furman University, USA 3Cell and Developmental Biology and the Vollum Institute for Advanced Biomedical Research, Oregon Health Sciences University, USAJudith GriselCarolyn RobbinsDavid Grandy
- Publication Details
- Neuroreport, Vol.8(16), pp.3431-3434
- Academic Unit
- Psychology, Department of
- Publisher
- Lippincott-Raven Publishers
- Identifiers
- 99900547866701842
- Language
- English
- Resource Type
- Journal article