Journal article
Antisense knockdown of neuronal nitric oxide synthase antagonizes nitrous oxide-induced behavior
Brain research, Vol.968(1), pp.167-170
2003
Handle:
https://hdl.handle.net/2376/106640
PMID: 12644275
Abstract
The behavioral effects of nitrous oxide (N
2O) were antagonized by non-specific inhibitors of nitric oxide synthase (NOS). To identify the isoform of NOS involved in this response, mice were pretreated with an antisense oligodeoxynucleotide (AS-ODN) against neuronal NOS, and then tested in a light/dark exploration paradigm. The AS-ODN but not the mismatch ODN significantly antagonized N
2O induced behavior and also reduced NOS activity in the cerebellum and hippocampus. These results implicate neuronal NOS in the N
2O response.
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Details
- Title
- Antisense knockdown of neuronal nitric oxide synthase antagonizes nitrous oxide-induced behavior
- Creators
- Shuang Li - Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, P.O. Box 646534, Pullman, WA 99164-6534, USAYang Dai - Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, WA, USARaymond M Quock - Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, P.O. Box 646534, Pullman, WA 99164-6534, USA
- Publication Details
- Brain research, Vol.968(1), pp.167-170
- Academic Unit
- Psychology, Department of
- Publisher
- Elsevier B.V
- Identifiers
- 99900546710201842
- Language
- English
- Resource Type
- Journal article