Journal article
Antiserum to prolactin decreases rapid eye movement sleep (REM sleep) in the male rat
Physiology & behavior, Vol.52(6), pp.1063-1068
1992
Handle:
https://hdl.handle.net/2376/101194
PMID: 1484861
Abstract
Previous reports suggest that blood-born prolactin (PRL) may selectively promote rapid eye movement sleep (REMS). To study the possible involvement of endogenous PRL in sleep regulation, rats were systemically injected with either antiserum to PRL or normal rabbit serum, and the sleep-wake activity was determined during the subsequent 12-h light cycle. The administration of normal rabbit serum in physiological saline did not alter sleep-wake activity compared to control recordings, whereas the PRL antiserum caused a modest and selective suppression in REMS. Immunoreactive PRL was eliminated from the serial plasma samples obtained between 6 to 11 h after the injection of the antiserum. Brain temperature was not affected by the antiserum. The results indicate that physiological pituitary PRL secretion has a slight REMS-promoting activity in the male rat. It is speculated that an increased release of pituitary PRL or the PRL-like substance previously demonstrated in the brain may significantly stimulate REMS.
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Details
- Title
- Antiserum to prolactin decreases rapid eye movement sleep (REM sleep) in the male rat
- Creators
- F Obál - Department of Physiology, A. Szent-Györgyi Medical University, Szeged, HungaryB Kacsóh - Department of Molecular and Cell Biology, Pennsylvania State University, University Park, PA 16802 USAP Alföldi - Department of Physiology, A. Szent-Györgyi Medical University, Szeged, HungaryL Payne - Department of Physiology and Biophysics, University of Tennessee, Memphis, TN 38163 USAO Markovic - Department of Physiology, A. Szent-Györgyi Medical University, Szeged, HungaryC Grosvenor - Department of Molecular and Cell Biology, Pennsylvania State University, University Park, PA 16802 USAJ.M Krueger - Department of Physiology and Biophysics, University of Tennessee, Memphis, TN 38163 USA
- Publication Details
- Physiology & behavior, Vol.52(6), pp.1063-1068
- Academic Unit
- Integrative Physiology and Neuroscience, Department of
- Publisher
- Elsevier Inc
- Identifiers
- 99900546684101842
- Language
- English
- Resource Type
- Journal article