Journal article
Array-based comparative genomic hybridization in clinical diagnosis
Expert review of molecular diagnostics, Vol.5(3), pp.421-429
05/01/2005
Handle:
https://hdl.handle.net/2376/103938
PMID: 15934818
Abstract
The sequencing of the human genome and development of high-throughput microarray technologies have enhanced the detection of copy number alterations in cancer research and the study of constitutional chromosomal abnormalities. Microarray-based comparative genomic hybridization (array CGH) has integrated molecular and traditional cytogenetics and has begun to impact the clinician's approach to medical genetics. Clinical applications of array CGH may define new genetic syndromes, expand the phenotype of existing syndromes and characterize a genomic signature of some cancers. As array CGH becomes the initial diagnostic approach for the investigation of constitutional and acquired chromosomal abnormalities, the combination of bioinformatics, robotics and microarray technology will set the stage for a new generation of high-resolution and high-throughput tools for genetic analysis, diagnosis and gene discovery.
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Details
- Title
- Array-based comparative genomic hybridization in clinical diagnosis
- Creators
- Bassem A Bejjani - Signature Genomic LaboratoriesAaron P Theisen - Health Research and Education CenterBlake C Ballif - Signature Genomic LaboratoriesLisa G Shaffer - Signature Genomic Laboratories
- Publication Details
- Expert review of molecular diagnostics, Vol.5(3), pp.421-429
- Academic Unit
- Center for Reproductive Biology; Medical Education and Clinical Science, Department of
- Publisher
- Taylor & Francis
- Identifiers
- 99900546705401842
- Language
- English
- Resource Type
- Journal article