Journal article
Ascending the nucleosome face: Recognition and function of structured domains in the histone H2A–H2B dimer
Biochimica et biophysica acta. Gene regulatory mechanisms, Vol.1819(8), pp.892-901
08/2012
Handle:
https://hdl.handle.net/2376/114936
PMCID: PMC3461831
PMID: 22521324
Abstract
Research over the past decade has greatly expanded our understanding of the nucleosome's role as a dynamic hub that is specifically recognized by many regulatory proteins involved in transcription, silencing, replication, repair, and chromosome segregation. While many of these nucleosome interactions are mediated by post-translational modifications in the disordered histone tails, it is becoming increasingly apparent that structured regions of the nucleosome, including the histone fold domains, are also recognized by numerous regulatory proteins. This review will focus on the recognition of structured domains in the histone H2A–H2B dimer, including the acidic patch, the H2A docking domain, the H2B α3-αC helices, and the HAR/HBR domains, and will survey the known biological functions of histone residues within these domains. Novel post-translational modifications and trans-histone regulatory pathways involving structured regions of the H2A–H2B dimer will be highlighted, along with the role of intrinsic disorder in the recognition of structured nucleosome regions.
► Reviews protein recognition of structural features in the histone H2A-H2B dimer. ► Describes novel post-translational modifications and trans-histone regulatory pathways involving the histone H2A-H2B dimer. ► Discusses the role of intrinsically disordered regions in recognizing structured histone regions.
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Details
- Title
- Ascending the nucleosome face: Recognition and function of structured domains in the histone H2A–H2B dimer
- Creators
- John J Wyrick - School of Molecular Biosciences, Washington State University, Pullman, WA 99164, USAMcKenna N.M Kyriss - School of Molecular Biosciences, Washington State University, Pullman, WA 99164, USAWilliam B Davis - School of Molecular Biosciences, Washington State University, Pullman, WA 99164, USA
- Publication Details
- Biochimica et biophysica acta. Gene regulatory mechanisms, Vol.1819(8), pp.892-901
- Academic Unit
- Molecular Biosciences, School of
- Publisher
- Elsevier B.V
- Identifiers
- 99900547856901842
- Language
- English
- Resource Type
- Journal article