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Journal article
Assessment of Glyphosate Induced Epigenetic Transgenerational Inheritance of Pathologies and Sperm Epimutations: Generational Toxicology
Scientific reports, Vol.9(1), pp.6372-6372
04/23/2019
PMCID: PMC6476885
PMID: 31011160
Abstract
Ancestral environmental exposures to a variety of factors and toxicants have been shown to promote the epigenetic transgenerational inheritance of adult onset disease. One of the most widely used agricultural pesticides worldwide is the herbicide glyphosate (N-(phosphonomethyl)glycine), commonly known as Roundup. There are an increasing number of conflicting reports regarding the direct exposure toxicity (risk) of glyphosate, but no rigorous investigations on the generational actions. The current study using a transient exposure of gestating F0 generation female rats found negligible impacts of glyphosate on the directly exposed F0 generation, or F1 generation offspring pathology. In contrast, dramatic increases in pathologies in the F2 generation grand-offspring, and F3 transgenerational greatgrand-offspring were observed. The transgenerational pathologies observed include prostate disease, obesity, kidney disease, ovarian disease, and parturition (birth) abnormalities. Epigenetic analysis of the F1, F2 and F3 generation sperm identified differential DNA methylation regions (DMRs). A number of DMR associated genes were identified and previously shown to be involved in pathologies. Therefore, we propose glyphosate can induce the transgenerational inheritance of disease and germline (e.g. sperm) epimutations. Observations suggest the generational toxicology of glyphosate needs to be considered in the disease etiology of future generations.
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Details
- Title
- Assessment of Glyphosate Induced Epigenetic Transgenerational Inheritance of Pathologies and Sperm Epimutations
- Creators
- Deepika Kubsad - Washington State Univ, Ctr Reprod Biol, Sch Biol Sci, Pullman, WA 99164 USAEric E. Nilsson - Washington State UniversityStephanie E. King - Washington State Univ, Ctr Reprod Biol, Sch Biol Sci, Pullman, WA 99164 USAIngrid Sadler-Riggleman - Washington State UniversityDaniel Beck - Washington State UniversityMichael K. Skinner - Washington State Univ, Ctr Reprod Biol, Sch Biol Sci, Pullman, WA 99164 USA
- Publication Details
- Scientific reports, Vol.9(1), pp.6372-6372
- Academic Unit
- Biological Sciences, School of
- Publisher
- Springer Nature
- Number of pages
- 17
- Grant note
- WSU Spokane Genomic Core laboratory 61174 / John Templeton Foundation
- Identifiers
- 99901080821501842
- Language
- English
- Resource Type
- Journal article