Journal article
Assessment of an 18F-Labeled Phosphoramidate Peptidomimetic as a New Prostate-Specific Membrane Antigen–Targeted Imaging Agent for Prostate Cancer
The Journal of nuclear medicine (1978), Vol.50(12), pp.2042-2048
12/2009
Handle:
https://hdl.handle.net/2376/107214
PMCID: PMC3575752
PMID: 19910433
Abstract
Prostate-specific membrane antigen (PSMA) is a transmembrane protein commonly found on the surface of late-stage and metastatic prostate cancer and a well-known imaging biomarker for staging and monitoring therapy. Although
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In-labeled caprop-mab pendetide is the only approved agent available for PSMA imaging, its clinical use is limited because of its slow distribution and clearance that leads to challenging image interpretation. A small-molecule approach using radiolabeled urea-based PSMA inhibitors as imaging agents has shown promise for prostate cancer imaging. The motivation of this work is to explore phosphoramidates as a new class of potent PSMA inhibitors to develop more effective prostate cancer imaging agents with improved specificity and clearance properties.
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Details
- Title
- Assessment of an 18F-Labeled Phosphoramidate Peptidomimetic as a New Prostate-Specific Membrane Antigen–Targeted Imaging Agent for Prostate Cancer
- Creators
- Suzanne E Lapi - Department of Radiology and Biomedical Imaging, Center for Molecular and Functional Imaging, University of California, San Francisco, CaliforniaHilla Wahnishe - Department of Radiology and Biomedical Imaging, Center for Molecular and Functional Imaging, University of California, San Francisco, CaliforniaDavid Pham - Department of Radiology and Biomedical Imaging, Center for Molecular and Functional Imaging, University of California, San Francisco, CaliforniaLisa Y Wu - Department of Chemistry, Washington State University, Pullman, WashingtonJessie R Nedrow-Byers - Department of Chemistry, Washington State University, Pullman, WashingtonTiancheng Liu - Department of Chemistry, Washington State University, Pullman, WashingtonKaveh Vejdani - Department of Radiology and Biomedical Imaging, Center for Molecular and Functional Imaging, University of California, San Francisco, CaliforniaHenry F VanBrocklin - Department of Radiology and Biomedical Imaging, Center for Molecular and Functional Imaging, University of California, San Francisco, CaliforniaClifford E Berkman - Department of Chemistry, Washington State University, Pullman, WashingtonElla F Jones - Department of Radiology and Biomedical Imaging, Center for Molecular and Functional Imaging, University of California, San Francisco, California
- Publication Details
- The Journal of nuclear medicine (1978), Vol.50(12), pp.2042-2048
- Academic Unit
- Chemistry, Department of
- Grant note
- R21 CA122126 || CA / National Cancer Institute : NCI
- Identifiers
- 99900546731001842
- Language
- English
- Resource Type
- Journal article