Journal article
Association of metabolic gene polymorphisms with alcohol consumption in controls
International journal of food sciences and nutrition, Vol.9(2), pp.180-189
03/2004
Handle:
https://hdl.handle.net/2376/107311
PMID: 15370874
Abstract
The objectives were to study the association between metabolic genes involved in alcohol metabolism (CYP2E1 RsaI, CYP2E1 DraI, ADH1C, NQO1) and alcohol consumption in a large sample of healthy controls. Healthy subjects were selected from the International Collaborative Study on Genetic Susceptibility to Environmental Carcinogens (GSEC). Subjects with information on both alcohol consumption and at least one of the studied polymorphisms were included in the analysis (n=2224). Information on the amount of alcohol consumption was available for a subset of subjects (n=844). None of the studied genes was significantly associated with drinking habits. A significant heterogeneity with age was observed when studying the association between CYP2E1 RsaI and alcohol drinking. CYP2E1 RsaI polymorphism was significantly associated with being a never drinker at older ages (odds ratio [OR] 2.4, 95% confidence interval [CI] 1.2-4.8; at ages above 68 years), while the association was reversed at ages below 47 years (OR 0.5, 95% CI 0.2-1.4). For subjects with detailed information on alcohol intake, no association between alcohol quantity and polymorphisms in metabolic genes was observed; subjects carrying the NQO1 polymorphism tended to drink more than subjects carrying the wild-type alleles. Therefore, no significant association between CYP2E1 RsaI, CYP2E1 DraI, ADH1C, NQO1 polymorphisms and alcohol consumption was observed in healthy controls.
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Details
- Title
- Association of metabolic gene polymorphisms with alcohol consumption in controls
- Creators
- S Raimondi - Molecular and Genetic Epidemiology Unit, Ospedale Policlinico IRCCS, Milan, ItalyS Benhamou - INSERM and Evry University, Evry, FranceC Coutelle - Université de Bordeaux II, Bordeaux, FranceS Garte - Genetics Research Institute, Milan, ItalyR Hayes - Occupational and Environmental Epidemiology Branch, National Cancer Institute, Bethesda, MD, USAL Kiemeney - University Medical Centre Nijmegen, Nijmegen, the NetherlandsP Lazarus - Penn State Cancer Institute, Penn State College of Medicine, Hershey, PA, USAL. Le Marchand - University of Hawaii, Honolulu, HI, USAS Morita - Yao Municipal Hospital, Osaka, JapanA Povey - Centre for Occupational and Environmental Health, University of Manchester, Manchester, UKM Romkes - University of Pittsburgh, Pittsburgh, PA, USAA Zijno - Istituto Superiore di Sanità, Rome, ItalyE Taioli - Molecular and Genetic Epidemiology Unit, Ospedale Policlinico IRCCS, Milan, Italy
- Publication Details
- International journal of food sciences and nutrition, Vol.9(2), pp.180-189
- Academic Unit
- Pharmaceutical Sciences, Department of
- Publisher
- Informa UK Ltd
- Identifiers
- 99900546773001842
- Language
- English
- Resource Type
- Journal article