Astrocytic Modulation of Sleep Homeostasis and Cognitive Consequences of Sleep Loss

Michael M Halassa; Cedrick Florian; Tommaso Fellin; James R Munoz; So-Young Lee; Ted Abel; Philip G Haydon; Marcos G Frank

doi:10.1016/j.neuron.2008.11.024

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Astrocytic Modulation of Sleep Homeostasis and Cognitive Consequences of Sleep Loss

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Astrocytic Modulation of Sleep Homeostasis and Cognitive Consequences of Sleep Loss

Michael M Halassa, Cedrick Florian, Tommaso Fellin, James R Munoz, So-Young Lee, Ted Abel, Philip G Haydon and Marcos G Frank

Neuron (Cambridge, Mass.), Vol.61(2), pp.213-219

2009

DOI: https://doi.org/10.1016/j.neuron.2008.11.024

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https://hdl.handle.net/2376/110243

PMCID: PMC2673052

PMID: 19186164

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https://doi.org/10.1016/j.neuron.2008.11.024View

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Abstract

Astrocytes modulate neuronal activity by releasing chemical transmitters via a process termed gliotransmission. The role of this process in the control of behavior is unknown. Since one outcome of SNARE-dependent gliotransmission is the regulation of extracellular adenosine and because adenosine promotes sleep, we genetically inhibited the release of gliotransmitters and asked if astrocytes play an unsuspected role in sleep regulation. Inhibiting gliotransmission attenuated the accumulation of sleep pressure, assessed by measuring the slow wave activity of the EEG during NREM sleep, and prevented cognitive deficits associated with sleep loss. Since the sleep-suppressing effects of the A1 receptor antagonist CPT were prevented following inhibition of gliotransmission and because intracerebroventricular delivery of CPT to wild-type mice mimicked the transgenic phenotype, we conclude that astrocytes modulate the accumulation of sleep pressure and its cognitive consequences through a pathway involving A1 receptors.

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Title: Astrocytic Modulation of Sleep Homeostasis and Cognitive Consequences of Sleep Loss
Creators: Michael M Halassa - Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Cedrick Florian - Department of Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Tommaso Fellin - Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
James R Munoz - Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
So-Young Lee - Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Ted Abel - Department of Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Philip G Haydon - Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Marcos G Frank - Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Publication Details: Neuron (Cambridge, Mass.), Vol.61(2), pp.213-219
Academic Unit: Biomedical Sciences, Department of
Publisher: Elsevier Inc
Identifiers: 99900547574601842
Language: English
Resource Type: Journal article