Journal article
Astroglial regulation of sleep homeostasis
Current opinion in neurobiology, Vol.23(5), pp.812-818
10/2013
Handle:
https://hdl.handle.net/2376/116825
PMID: 23518138
Abstract
Mammalian sleep is regulated by two distinct mechanisms. A circadian oscillator provides timing signals that organize sleep and wake across the 24 hour day. A homeostatic mechanism increases sleep drive and sleep amounts (or intensity) as a function of prior time awake. The cellular mechanisms of sleep homeostasis are poorly defined, but are thought to be primarily neuronal. According to one view, sleep homeostasis arises from interactions between subcortical neurons that register sleep pressure and other neurons that promote either sleep or wakefulness. Alternatively, sleep drive may arise independently among neurons throughout the brain in a use-dependent fashion. Implicit in both views is the idea that sleep homeostasis is solely the product of neurons. In this article, I discuss an emerging view that glial astrocytes may play an essential role in sleep homeostasis.
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Details
- Title
- Astroglial regulation of sleep homeostasis
- Creators
- Marcos G Frank - University of Pennsylvania, Perelman School of Medicine, Department of Neuroscience, 215 Stemmler Hall, 35th & Hamilton Walk, Philadelphia, PA 19104-6074, United States. Electronic address: mgf@mail.med.upenn.edu
- Publication Details
- Current opinion in neurobiology, Vol.23(5), pp.812-818
- Academic Unit
- Biomedical Sciences, Department of
- Publisher
- England
- Grant note
- R01 MH099544 / NIMH NIH HHS
- Identifiers
- 99900547402901842
- Language
- English
- Resource Type
- Journal article