Journal article
Asymmetric Multicomponent [C+NC+CC] Synthesis of Highly Functionalized Pyrrolidines Catalyzed by Silver(I)
Organic letters, Vol.8(17), pp.3647-3650
08/17/2006
Handle:
https://hdl.handle.net/2376/104945
PMID: 16898782
Abstract
Highly functionalized pyrrolidines are obtained in a single chemical step via a mild, efficient, and selective AgI-catalyzed asymmetric [C+NC+CC] coupling process. Oppolzer's camphorsultam enables the desired reaction cascade and provides a reliable means to control the developing stereochemistry and purify the products. This three-component reaction provides unprecedented access to structurally diverse pyrrolidines for both target- and diversity-oriented syntheses.
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Details
- Title
- Asymmetric Multicomponent [C+NC+CC] Synthesis of Highly Functionalized Pyrrolidines Catalyzed by Silver(I)
- Creators
- Philip GarnerH. Ümit KaniskanJieyu HuWiley J YoungsMatthew Panzner
- Publication Details
- Organic letters, Vol.8(17), pp.3647-3650
- Academic Unit
- Chemistry, Department of
- Publisher
- American Chemical Society
- Identifiers
- 99900546872901842
- Language
- English
- Resource Type
- Journal article